公开(公告)号：US20200291488A1

公开(公告)日：2020-09-17

申请号：US16613702

申请日：2018-05-17

Applicant: T2 Biosystems, Inc.

Inventor： Brendan John MANNING ,  Jessica Lee SNYDER ,  Benjamin Nguyen CHANG ,  Trissha Ritsue HIGA ,  Robert Patrick SHIVERS ,  Yin Shan Cathy WONG ,  Thomas Jay LOWERY, Jr. ,  Urvi VED ,  Daniel GAMERO

IPC: C12Q1/6895 ,  C12N1/06 ,  G01N33/543 ,  C12Q1/06 ,  C12Q1/6806 ,  C12N15/11 ,  A61K38/08 ,  G01N24/08 ,  G01R33/44

Abstract: The invention features methods, systems, and panels for rapid detection of Candida species (e.g., Candida auris, Candida lusitaniae, Candida haemulonii, Candida duobushaemulonii, and Candida pseudohaemulonii) in biological samples (e.g., whole blood) and environmental samples (e.g., environmental swabs, e.g., surface swabs), and for diagnosis and monitoring of diseases, including Candidiasis and sepsis.

公开(公告)号：US20220372555A1

公开(公告)日：2022-11-24

申请号：US17617784

申请日：2020-06-10

Applicant: T2 Biosystems, Inc.

Inventor： Jessica Lee SNYDER ,  Daniel GAMERO ,  Robert Patrick SHIVERS ,  Kristen ROBERTS ,  Joseph MARTURANO ,  Thomas J. LOWERY, Jr. ,  Roger SMITH ,  Brendan John MANNING

IPC: C12Q1/689 ,  B01L3/00

Abstract: Provided herein are methods of amplifying and detecting biothreat pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

公开(公告)号：US20220348986A1

公开(公告)日：2022-11-03

申请号：US17620230

申请日：2020-06-19

Applicant: T2 Biosystems, Inc.

Inventor： Jessica Lee SNYDER ,  Joseph MARTURANO ,  Sandy ESTRADA ,  Robert Patrick SHIVERS ,  Roger SMITH ,  Brendan John MANNING ,  Thomas J. LOWERY, Jr. ,  Daniel GAMERO ,  Mohamed Nabuan NAUFER ,  Kelly N. BURGESS

IPC: C12Q1/689 ,  C12Q1/6895

Abstract: Provided herein are methods of amplifying and detecting pathogens and drug resistance markers (e.g., antibiotic resistance genes) in complex samples (e.g., blood), as well as related panels and compositions (e.g., primers, probes, magnetic particles, systems, cartridges, and kits). The methods, panels, and compositions can be used for comprehensive detection of pathogens and drug resistance markers for patient identification, patient selection, optimization of therapies, and antimicrobial stewardship.