公开(公告)号：US20220348986A1

公开(公告)日：2022-11-03

申请号：US17620230

申请日：2020-06-19

Applicant: T2 Biosystems, Inc.

Inventor： Jessica Lee SNYDER ,  Joseph MARTURANO ,  Sandy ESTRADA ,  Robert Patrick SHIVERS ,  Roger SMITH ,  Brendan John MANNING ,  Thomas J. LOWERY, Jr. ,  Daniel GAMERO ,  Mohamed Nabuan NAUFER ,  Kelly N. BURGESS

IPC: C12Q1/689 ,  C12Q1/6895

Abstract: Provided herein are methods of amplifying and detecting pathogens and drug resistance markers (e.g., antibiotic resistance genes) in complex samples (e.g., blood), as well as related panels and compositions (e.g., primers, probes, magnetic particles, systems, cartridges, and kits). The methods, panels, and compositions can be used for comprehensive detection of pathogens and drug resistance markers for patient identification, patient selection, optimization of therapies, and antimicrobial stewardship.

公开(公告)号：US20220372555A1

公开(公告)日：2022-11-24

申请号：US17617784

申请日：2020-06-10

Applicant: T2 Biosystems, Inc.

Inventor： Jessica Lee SNYDER ,  Daniel GAMERO ,  Robert Patrick SHIVERS ,  Kristen ROBERTS ,  Joseph MARTURANO ,  Thomas J. LOWERY, Jr. ,  Roger SMITH ,  Brendan John MANNING

IPC: C12Q1/689 ,  B01L3/00

Abstract: Provided herein are methods of amplifying and detecting biothreat pathogens in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

公开(公告)号：US20220282310A1

公开(公告)日：2022-09-08

申请号：US17274911

申请日：2019-09-10

Applicant: T2 Biosystems, Inc.

Inventor： Jessica Lee SNYDER ,  Brendan John MANNING ,  Christopher STEELE ,  Roger SMITH ,  Heidi Susanne GIESE ,  Yin Shan Cathy WONG ,  Daniel GAMERO ,  Thomas J. LOWERY, Jr.

IPC: C12Q1/6825 ,  C12Q1/6869 ,  C12Q1/6806

Abstract: Provided herein are methods of detecting and sequencing target nucleic acids in complex samples (e.g., blood), as well as related panels and compositions (e.g., systems, cartridges, and kits).

公开(公告)号：US20180188195A1

公开(公告)日：2018-07-05

申请号：US15738754

申请日：2016-06-27

Applicant: T2 Biosystems, Inc.

Inventor： Eugenio DAVISO ,  Lucius (Tad) FOX ,  Thomas Jay LOWERY, Jr. ,  Joseph MARTURANO ,  Vyacheslav PAPKOV ,  Al SCHROFF ,  Roger SMITH ,  Zhixiang LUO

IPC: G01N24/08 ,  G01R33/44 ,  C12Q1/56

CPC classification number: G01N24/088 ,  C12Q1/56 ,  G01N24/08 ,  G01N2333/974 ,  G01R33/448

Abstract: The invention features a diagnostic platform utilizing T2 magnetic resonance to directly measure integrated reactions in whole blood samples such as clotting, fibrinogen, clot contraction, and fibrinolysis to provide a comprehensive assessment of hemostatic parameters on a single instrument in minutes. The methods of the invention can be performed with less than 1 ml of blood and minimal sample handling.