公开(公告)号：US20250089722A1

公开(公告)日：2025-03-20

申请号：US18963593

申请日：2024-11-28

Applicant: T3 BIOSCIENCE, INC. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A01N63/27 ,  A01N43/40 ,  A01P3/00

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, and the cell broth and novel metabolites produced from the bacterial strains, to inhibit the growth of a variety of pathogenic microorganism for a variety of crops. This method is effective against a broad range of fungal pathogens, including Pythium aphanidermatum, Podosphaera xanthii, Plasmopara viticola, Erysiphe cichoracearum, Pseudoperonospora cubensis, Clarireedia jacksonii, Microdochium nivale, and Podosphaera leucotricha. The methods include the application of Formula (I) in various formulations to inhibit pathogenic microorganisms in crops such as cucurbits, legumes, leafy greens, root vegetables, oilseed crops, ornamental plants, fruit crops, and turfgrass. The methods include the use of an agricultural composition including a novel, potent antimicrobial metabolite produced from the bacterial strains corresponding to the compound having Formula (I):

公开(公告)号：US12121552B2

公开(公告)日：2024-10-22

申请号：US18120528

申请日：2023-03-13

Applicant: T3 Bioscience, Inc. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A61K35/74 ,  A61K31/05 ,  A61P31/04

CPC classification number: A61K35/74 ,  A61K31/05 ,  A61P31/04

Abstract: The present invention relates to an antimicrobial composition and probiotics against bacterial and fungal pathogens of fish. In particular, the invention pertains to a novel strain of the bacterial species Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (ATCC accession number PTA-126941), the cells, cell broth, and novel metabolites produced from the bacterial strain that can inhibit the growth of a variety of fish pathogens.

公开(公告)号：US12089595B2

公开(公告)日：2024-09-17

申请号：US17493594

申请日：2021-10-04

Applicant: T3 Bioscience, Inc. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A01N43/40 ,  A01N63/27 ,  A01P1/00 ,  A01P3/00

CPC classification number: A01N43/40 ,  A01N63/27 ,  A01P1/00 ,  A01P3/00

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops and fungal pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US12167733B2

公开(公告)日：2024-12-17

申请号：US18103082

申请日：2023-01-30

Applicant: T3 BIOSCIENCE, Inc. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Xiangyang Liu

IPC: A01N63/27 ,  A61K35/74 ,  C07D213/90 ,  C07D491/048 ,  C12N1/20

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US20230165260A1

公开(公告)日：2023-06-01

申请号：US18103082

申请日：2023-01-30

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Xiangyang Liu

IPC: A01N63/27 ,  C12N1/20 ,  C07D213/90 ,  C07D491/048 ,  A61K35/74

CPC classification number: A01N63/27 ,  C12N1/20 ,  C07D213/90 ,  C07D491/048 ,  A61K35/74 ,  C07B2200/13

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US20230285472A1

公开(公告)日：2023-09-14

申请号：US18120528

申请日：2023-03-13

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A61K35/74 ,  A61K31/05 ,  A61P31/04

CPC classification number: A61K35/74 ,  A61K31/05 ,  A61P31/04

Abstract: The present invention relates to an antimicrobial composition and probiotics against bacterial and fungal pathogens of fish. In particular, the invention pertains to a novel strain of the bacterial species Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (ATCC accession number PTA-126941), the cells, cell broth, and novel metabolites produced from the bacterial strain that can inhibit the growth of a variety of fish pathogens.

公开(公告)号：US11590115B2

公开(公告)日：2023-02-28

申请号：US17494068

申请日：2021-10-05

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A61K31/04 ,  A61K31/4412 ,  A61P31/04 ,  A61K35/74

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of fish pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to a compound having Formula (I):

公开(公告)号：US20220105080A1

公开(公告)日：2022-04-07

申请号：US17494068

申请日：2021-10-05

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A61K31/4412 ,  A61K35/74 ,  A61P31/04

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of fish pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to a compound having Formula (I):

公开(公告)号：US11582973B2

公开(公告)日：2023-02-21

申请号：US17063540

申请日：2020-10-05

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Xiangyang Liu

IPC: A01N63/27 ,  C12N1/20 ,  C07D213/90 ,  C07D491/048 ,  A61K35/74

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US20230309565A1

公开(公告)日：2023-10-05

申请号：US18120799

申请日：2023-03-13

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A01N63/27 ,  A01H6/78 ,  A01H1/00

CPC classification number: A01N63/27 ,  A01H1/125 ,  A01H6/785

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, to inhibit the growth of a variety of microbial species for bacterial pathogens that cause citrus Huanglongbing (citrus greening disease), Zebra chip (ZC) disease of potato, tomato, and other plants of the family Solanaceae and plants of the family Apiaceae and Umbelliferae. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to a Pseudomonas bacterial metabolite as Formula (I):