公开(公告)号：US20250089722A1

公开(公告)日：2025-03-20

申请号：US18963593

申请日：2024-11-28

Applicant: T3 BIOSCIENCE, INC. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A01N63/27 ,  A01N43/40 ,  A01P3/00

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, and the cell broth and novel metabolites produced from the bacterial strains, to inhibit the growth of a variety of pathogenic microorganism for a variety of crops. This method is effective against a broad range of fungal pathogens, including Pythium aphanidermatum, Podosphaera xanthii, Plasmopara viticola, Erysiphe cichoracearum, Pseudoperonospora cubensis, Clarireedia jacksonii, Microdochium nivale, and Podosphaera leucotricha. The methods include the application of Formula (I) in various formulations to inhibit pathogenic microorganisms in crops such as cucurbits, legumes, leafy greens, root vegetables, oilseed crops, ornamental plants, fruit crops, and turfgrass. The methods include the use of an agricultural composition including a novel, potent antimicrobial metabolite produced from the bacterial strains corresponding to the compound having Formula (I):

公开(公告)号：US20240327421A1

公开(公告)日：2024-10-03

申请号：US18444414

申请日：2024-02-16

Applicant: Marquette University ,  Concordia University, Inc. ,  UWM Research Foundation, Inc.

Inventor： William A. Donaldson ,  Daniel S. Sem ,  Karyn M. Frick

IPC: C07D493/08 ,  A61P25/28 ,  C07C35/21

CPC classification number: C07D493/08 ,  A61P25/28 ,  C07C35/21

Abstract: Disclosed are substituted (4′-hydroxylphenyl) cycloalkane compounds and substituted (4′-hydroxylphenyl) cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.

公开(公告)号：US20240279232A1

公开(公告)日：2024-08-22

申请号：US18567191

申请日：2021-06-07

Applicant: UWM Research Foundation, Inc.

Inventor： Alexander E. Arnold ,  Douglas C. Stafford ,  James M. Cook ,  Amanda N. Nieman ,  Michael Ming-Jin Poe ,  Guanguan Li

IPC: C07D487/04 ,  A61K31/5517 ,  A61P29/00

CPC classification number: C07D487/04 ,  A61K31/5517 ,  A61P29/00

Abstract: Substituted 5-(4-methyl-6-phenyl-4H-benzo[f]imidazo[1,5-a][1.4]diazepin-3-yl)-1.2.4-oxadiazole compounds are ligands for the k opioid receptor and inhibit inducible nitric oxide synthase. The compounds have utility to inhibit NO production and treat associated inflammatory conditions.

公开(公告)号：US11859380B2

公开(公告)日：2024-01-02

申请号：US17592073

申请日：2022-02-03

Applicant: UWM Research Foundation, Inc.

Inventor： Jian Zhao

IPC: F16B13/14 ,  E04B1/41 ,  E21B10/44

CPC classification number: E04B1/4157 ,  E21B10/44

Abstract: A cured concrete and stone bore working tool and method of forming radially oriented discontinuities in a bore or perforation formed in a cured concrete or stone material such that, after use or application of the tool, the perforation formed in the cured concrete or stone material is configured to provide a non-planar adhesive interface and isolate a properly sized anchor or fastener from direct contact with the wall of the bore. Fasteners or anchors adhesively secured in bores previously treated with the bore treating tool exhibit improved creep failure performance as compared to fasteners adhesively secured to untreated bores.

公开(公告)号：US20230165260A1

公开(公告)日：2023-06-01

申请号：US18103082

申请日：2023-01-30

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Xiangyang Liu

IPC: A01N63/27 ,  C12N1/20 ,  C07D213/90 ,  C07D491/048 ,  A61K35/74

CPC classification number: A01N63/27 ,  C12N1/20 ,  C07D213/90 ,  C07D491/048 ,  A61K35/74 ,  C07B2200/13

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US20220003684A1

公开(公告)日：2022-01-06

申请号：US17291690

申请日：2019-11-08

Applicant: UWM Research Foundation, Inc.

Inventor： Jian Chen ,  Seyedali Banisadr ,  Adebola Olatunji Oyefusi

IPC: G01N21/78

Abstract: A three-layer system composed of a substrate, a metal or metal alloy thin film deposited on the substrate surface, and an overlaid stimulus-responsive polymer layer detects changes in environmental conditions brought about by physical, chemical, or biological stimuli. The thin metal or metal alloy film functions as an optical filter and the polymer layer changes properties (e.g., dimensions) in response to changing environmental conditions that manifests as a change in wavelength of reflected or filtered light. The system is useful in colorimetric sensors.

公开(公告)号：US20210370205A1

公开(公告)日：2021-12-02

申请号：US17286124

申请日：2019-10-17

Applicant: UWM Research Foundation, Inc.

Inventor： Yin Wang ,  Shangping Xu ,  Haiyan Yang ,  John Bender

IPC: B01D39/06 ,  C04B38/06 ,  C04B33/04 ,  C04B33/32 ,  C04B33/13 ,  C04B38/00 ,  A61L2/02 ,  B01D39/20 ,  C02F1/00

Abstract: A filter material composing a ceramic clay having an interconnected network of pores formed from cellulose fiber combustion is useful for removing chemical and biological contaminants from a water supply. Coating the ceramic clay with lanthanum enhances the removal of anionic species of As(V), As(III), Cr(VI), microbes and virus.

公开(公告)号：US20210254972A1

公开(公告)日：2021-08-19

申请号：US17169331

申请日：2021-02-05

Applicant: UWM Research Foundation, Inc.

Inventor： Marcia Renata Quadros da Silva ,  Sachin Davis ,  Adibi Yasaman

IPC: G01B17/02

Abstract: A system for detecting the presence of biofilm on an inner surface of a body used for containing a fluid medium. The system includes a transmitter disposed at a first location external to the body, a receiver located at a second location external to the body, and an electronic controller. The electronic controller configured to control the transmitter to transmit an ultrasonic signal in a direction towards the body and receive, via the receiver, an attenuated signal that is the ultrasonic signal after passing through the body. The electronic controller is configured to determine a phase shift between the ultrasonic signal and the attenuated ultrasonic signal, determine an amplitude difference between the ultrasonic signal and the attenuated ultrasonic signal, and generate an indication of an amount of biofilm present on the inner surface of the body based on the phase shift and the amplitude difference.

公开(公告)号：US20210121866A1

公开(公告)日：2021-04-29

申请号：US17079280

申请日：2020-10-23

Applicant: UWM Research Foundation, Inc.

Inventor： Mark Dietz ,  Abdul Momen ,  Charles Smith

IPC: B01J39/05 ,  B01J39/16 ,  B01J47/018 ,  B01J47/02 ,  B01D15/20 ,  B01D15/42 ,  B01D15/36

Abstract: Disclosed herein are extraction chromatographic supports comprising a porous support, an inert filler, and metal ion binding extractant that may be used for chromatographic separation of metal ions. Also disclosed herein are methods for preparing and using the extraction chromatographic supports.

公开(公告)号：US20190327944A1

公开(公告)日：2019-10-31

申请号：US16399600

申请日：2019-04-30

Applicant: UWM Research Foundation, Inc. ,  Harbor District, Inc.

Inventor： Lindsay Frost ,  Geoffrey Anderson

IPC: A01K61/78 ,  A01G33/00 ,  A01G24/42

Abstract: An aquatic habitat structure mountable with a bulkhead includes an elongate body including a longitudinal axis, and a mounting member configured to couple the elongate body to the bulkhead. The aquatic habitat structure additionally includes one or more modular habitats, and one or more mounting brackets, wherein each of the one or more mounting brackets are configured to couple at least one of the one or more modular habitats to the elongate body.