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公开(公告)号：US09676773B2
公开(公告)日：2017-06-13
申请号：US15112070
申请日：2015-02-04
IPC分类号： C07D401/14 , A61K31/437 , C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/5377 , A61K31/695 , C07D471/04
摘要： Provided is a novel compound having a selective JAK3-inhibitory effect and also having excellent oral absorbability. Also provided is a pharmaceutical agent, which is based on a JAK3-inhibitory effect and is useful for preventing and/or treating a disease involving the JAK3, and in particular, rheumatoid arthritis or multiple sclerosis.An azaindole derivative having a cycloalkenyl group, which is represented by the following formula (I), or a salt thereof, and a pharmaceutical composition containing the same: where R1 to R4, m and n have the same meanings as those defined in the description.
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公开(公告)号：US09782392B2
公开(公告)日：2017-10-10
申请号：US15404253
申请日：2017-01-12
IPC分类号： C07D401/14 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K31/695
CPC分类号： A61K31/437 , A61K31/444 , A61K31/5377 , A61K31/695 , C07D471/04
摘要： A method for treating rheumatoid arthritis, multiple sclerosis, or a disease involving JAK3, including administering a compound of the formula (I) or a salt thereof to a subject
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![Pyrrolo[2,3-d]pyrimidine compound or salt thereof](/abs-image/US/2019/09/24/US10421760B2/abs.jpg.150x150.jpg)
公开(公告)号：US10421760B2
公开(公告)日：2019-09-24
申请号：US15746208
申请日：2016-07-29
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61K47/32 , C07D207/30 , C07D307/34 , A61P29/00
摘要： Provided are a novel compound or a salt thereof, and a pharmaceutical composition comprising the same, which selectively and strongly inhibit JAK3, exhibit an excellent activity for suppressing the growth of human peripheral blood monocytes and an excellent oral absorbability, and exhibits an activity of inhibiting IL-2-induced IFN-γ production in vivo. A compound represented by formula (I) [wherein X represents —CH═CH—, —NH—, a sulfur atom or an oxygen atom; and n represents an integer of 0 to 2], or a salt thereof.
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