公开(公告)号：US3923807A

公开(公告)日：1975-12-02

申请号：US39544873

申请日：1973-09-10

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： FURUKAWA YOSHIYASU ,  SUNO MASAHIRO ,  NOSE SAWAMI

IPC: C07D239/54 ,  C07D239/06

CPC classification number: C07D239/54 ,  Y10S514/822 ,  Y10S514/869

Abstract: Novel 6-aminouracil derivatives of the formula

WHEREIN R1 is lower alkyl which may be substituted with hydroxy or lower alkoxy, R2 is halogen, nitro or lower alkyl and n is 0, 1 or 2, show a strong inhibitory action against adenosine -3'', 5'' cyclic phosphate phosphodiesterase in vitro, and exhibit excellent pharmacological actions such as diuretic, platelet aggregation inhibitory and broncho-dilating actions.

D R A W I N G

Abstract translation: 新颖的式6-氨基尿嘧啶衍生物，其中，R 1为可被羟基或低级烷氧基取代的低级烷基，R 2为卤素，硝基或低级烷基，n为0,1或2，对腺苷-3' 5'环磷酸二酯酶，体外表现出优异的药理作用，如利尿，血小板聚集抑制和支气管扩张作用。

公开(公告)号：US3666748A

公开(公告)日：1972-05-30

申请号：US3666748D

申请日：1968-12-17

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HONJO MIKIO ,  FURUKAWA YOSHIYASU

IPC: C07F9/24 ,  C07H19/10

CPC classification number: C07H19/10 ,  C07F9/24

Abstract: Cytidine-5''-diphosphate choline and deoxycytidine-5''-diphosphate choline are produced by reacting cytidine (or deoxycytidine)-5''monophosphate with a choline phosphoramidate. Choline phosphoramidates of the formula WHEREIN R1 and R2 represent hydrogen, a hydrocarbon residue having at most seven carbon atoms, or R1 and R2 taken together represent a five- or six-membered heterocyclic ring are prepared by reacting phosphorylcholine with an amine.

Abstract translation: 胞苷-5'-二磷酸胆碱和脱氧胞苷-5'-二磷酸胆碱通过胞苷（或脱氧胞苷）-5'-单磷酸与氨基磷酸胆碱反应产生。 式WHEREIN R1和R2代表氢，具有至多7个碳原子的烃残基或R1和R2一起代表五元或六元杂环的胆碱磷酸亚氨基酯是通过使磷酰胆碱与胺反应来制备的。

公开(公告)号：US3444158A

公开(公告)日：1969-05-13

申请号：US3444158D

申请日：1966-10-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HONJO MIKIO ,  IMAI KIN-ICHI ,  FURUKAWA YOSHIYASU

IPC: C07H1/02 ,  C07D51/50

CPC classification number: C07H1/02