公开(公告)号：US10435445B2

公开(公告)日：2019-10-08

申请号：US15941030

申请日：2018-03-30

申请人： Takeda Pharmaceutical Company Limited

发明人： Taiji Asami ,  Naoki Nishizawa ,  Ayumu Niida ,  Yoko Kanematsu ,  Mari Adachi ,  Shiro Takekawa ,  Tomoko Morimoto

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/605 ,  A61K47/60 ,  A61P1/08

摘要： The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. (I) P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13- A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25- A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37- A38-A39-A40-P2 wherein each symbol is as defined herein.

公开(公告)号：US09200051B2

公开(公告)日：2015-12-01

申请号：US14287514

申请日：2014-05-27

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Taiji Asami ,  Ayumu Niida

IPC分类号： C07K14/605

CPC分类号： C07K14/605 ,  A61K38/00

摘要： The present invention provides a novel peptide compound having an activating action on GLP-1 receptors and GIP receptors and use of the peptide compound as a medicament. Specifically, a peptide containing a partial sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-Aib-Glu-Gly-Thr-αMePhe-Thr-Ser-Asp-Tyr-A11-A12-A13-Leu-Asp-A16-A17-Ala-Gln-A20-Glu-Phe-Val-Lys-Trp-Leu-Leu-Lys-A29 SEQ ID NO: 1 (I)wherein each symbol is as defined herein.

摘要翻译： 本发明提供了对GLP-1受体和GIP受体具有活化作用的新型肽化合物以及肽化合物作为药物的用途。 具体地，提供含有由式（I）表示的部分序列的肽或其盐和包含其的药物。 P1-Tyr-Aib-Glu-Gly-Thr-αMePhe-Thr-Ser-Asp-Tyr-A11-A12-A13-Leu-Asp-A16-A17-Ala-Gln-A20-Glu-Phe-Val-Lys- Trp-Leu-Leu-Lys-A29 SEQ ID NO：1（I）其中每个符号如本文所定义。

公开(公告)号：US12122815B2

公开(公告)日：2024-10-22

申请号：US17279266

申请日：2019-09-24

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Hiroshi Imoto ,  Mari Adachi ,  Yoko Kanematsu ,  Taiji Asami ,  Ayumu Niida ,  Naoki Nishizawa ,  Derek Cecil Cole ,  Mack Flinspach ,  Nick Scorah ,  Abhijit Suresh Bhat

IPC分类号： C07K14/575 ,  A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K38/00 ,  A61K47/02 ,  A61P1/08

CPC分类号： C07K14/575 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2059 ,  A61K47/02 ,  A61P1/08 ,  A61K38/00

摘要： The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 328-893.

公开(公告)号：US11174301B2

公开(公告)日：2021-11-16

申请号：US16555085

申请日：2019-08-29

申请人： Takeda Pharmaceutical Company Limited

发明人： Taiji Asami ,  Naoki Nishizawa ,  Ayumu Niida ,  Yoko Kanematsu ,  Mari Adachi ,  Shiro Takekawa ,  Tomoko Morimoto

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/605 ,  A61K47/60 ,  A61P1/08

摘要： The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.
Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2   (I) wherein each symbol is as defined herein.

公开(公告)号：US20180298070A1

公开(公告)日：2018-10-18

申请号：US15941030

申请日：2018-03-30

申请人： Takeda Pharmaceutical Company Limited

发明人： Taiji Asami ,  Naoki Nishizawa ,  Ayumu Niida ,  Yoko Kanematsu ,  Mari Adachi ,  Shiro Takekawa ,  Tomoko Morimoto

IPC分类号： C07K14/47 ,  A61K47/60 ,  A61P1/08

CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K47/60 ,  A61P1/08 ,  C07K14/605

摘要： The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2   (I) wherein each symbol is as defined herein.

公开(公告)号：US10087229B2

公开(公告)日：2018-10-02

申请号：US14780579

申请日：2014-05-27

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Taiji Asami ,  Ayumu Niida

IPC分类号： C07K14/605 ,  A61K38/00

摘要： The present invention provides a novel peptide compound having an activating action on GLP-1 receptors and GIP receptors and use of the peptide compound as a medicament. Specifically, a peptide containing a partial sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-Aib-Glu-Gly-Thr-alphaMePhe-Thr-Ser-Asp-Tyr-A11-A12-A13-Leu-Asp-A16-A17-Ala-Gln-A20-Glu-Phe-Val-Lys-Trp-Leu-Leu-Lys-A29 (I) wherein each symbol is as defined herein.