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公开(公告)号：US12122815B2
公开(公告)日：2024-10-22
申请号：US17279266
申请日：2019-09-24
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Hiroshi Imoto , Mari Adachi , Yoko Kanematsu , Taiji Asami , Ayumu Niida , Naoki Nishizawa , Derek Cecil Cole , Mack Flinspach , Nick Scorah , Abhijit Suresh Bhat
CPC classification number: C07K14/575 , A61K9/0019 , A61K9/08 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K47/02 , A61P1/08 , A61K38/00
Abstract: The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 328-893.
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公开(公告)号：US11174301B2
公开(公告)日：2021-11-16
申请号：US16555085
申请日：2019-08-29
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Taiji Asami , Naoki Nishizawa , Ayumu Niida , Yoko Kanematsu , Mari Adachi , Shiro Takekawa , Tomoko Morimoto
IPC: A61K38/00 , C07K14/47 , C07K14/605 , A61K47/60 , A61P1/08
Abstract: The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.
Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2 (I) wherein each symbol is as defined herein.-
公开(公告)号：US20180298070A1
公开(公告)日：2018-10-18
申请号：US15941030
申请日：2018-03-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Taiji Asami , Naoki Nishizawa , Ayumu Niida , Yoko Kanematsu , Mari Adachi , Shiro Takekawa , Tomoko Morimoto
CPC classification number: C07K14/4705 , A61K38/00 , A61K47/60 , A61P1/08 , C07K14/605
Abstract: The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2 (I) wherein each symbol is as defined herein.
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公开(公告)号：US10435445B2
公开(公告)日：2019-10-08
申请号：US15941030
申请日：2018-03-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Taiji Asami , Naoki Nishizawa , Ayumu Niida , Yoko Kanematsu , Mari Adachi , Shiro Takekawa , Tomoko Morimoto
IPC: A61K38/00 , C07K14/47 , C07K14/605 , A61K47/60 , A61P1/08
Abstract: The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. (I) P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13- A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25- A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37- A38-A39-A40-P2 wherein each symbol is as defined herein.
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