公开(公告)号：US12202832B2

公开(公告)日：2025-01-21

申请号：US16608723

申请日：2018-04-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shuji Kitamura ,  Zenichi Ikeda ,  Minoru Ikoma ,  Koji Watanabe ,  Hideki Hirose ,  Takafumi Yukawa ,  Sachie Morimoto ,  Naoki Nishizawa ,  Taiji Asami

IPC: C07D487/04 ,  A61K9/20 ,  A61K9/48 ,  A61K31/4184 ,  A61K47/38 ,  A61P9/04

Abstract: The present invention provides a compound or a salt thereof having a calcium-sensing receptor antagonistic activity, and being expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like. The compounds represented by formula (I) or a salt thereof has a calcium-sensing receptor antagonistic activity, and is expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like, wherein each symbol is as described in the specification.

公开(公告)号：US12122815B2

公开(公告)日：2024-10-22

申请号：US17279266

申请日：2019-09-24

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Hiroshi Imoto ,  Mari Adachi ,  Yoko Kanematsu ,  Taiji Asami ,  Ayumu Niida ,  Naoki Nishizawa ,  Derek Cecil Cole ,  Mack Flinspach ,  Nick Scorah ,  Abhijit Suresh Bhat

IPC: C07K14/575 ,  A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K38/00 ,  A61K47/02 ,  A61P1/08

CPC classification number: C07K14/575 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2059 ,  A61K47/02 ,  A61P1/08 ,  A61K38/00

Abstract: The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 328-893.

公开(公告)号：US11174301B2

公开(公告)日：2021-11-16

申请号：US16555085

申请日：2019-08-29

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Taiji Asami ,  Naoki Nishizawa ,  Ayumu Niida ,  Yoko Kanematsu ,  Mari Adachi ,  Shiro Takekawa ,  Tomoko Morimoto

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/605 ,  A61K47/60 ,  A61P1/08

Abstract: The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.
Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2   (I) wherein each symbol is as defined herein.

公开(公告)号：US20180298070A1

公开(公告)日：2018-10-18

申请号：US15941030

申请日：2018-03-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Taiji Asami ,  Naoki Nishizawa ,  Ayumu Niida ,  Yoko Kanematsu ,  Mari Adachi ,  Shiro Takekawa ,  Tomoko Morimoto

IPC: C07K14/47 ,  A61K47/60 ,  A61P1/08

CPC classification number: C07K14/4705 ,  A61K38/00 ,  A61K47/60 ,  A61P1/08 ,  C07K14/605

Abstract: The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37-A38-A39-A40-P2   (I) wherein each symbol is as defined herein.

公开(公告)号：US10435445B2

公开(公告)日：2019-10-08

申请号：US15941030

申请日：2018-03-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Taiji Asami ,  Naoki Nishizawa ,  Ayumu Niida ,  Yoko Kanematsu ,  Mari Adachi ,  Shiro Takekawa ,  Tomoko Morimoto

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/605 ,  A61K47/60 ,  A61P1/08

Abstract: The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament.Specifically, a peptide containing a sequence represented by the formula (I) or a salt thereof and a medicament comprising the same are provided. (I) P1-Tyr-A2-Glu-Gly-Thr-A6-A7-A8-A9-A10-A11-A12-A13- A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25- A26-A27-A28-A29-A30-A31-A32-A33-A34-A35-A36-A37- A38-A39-A40-P2 wherein each symbol is as defined herein.