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公开(公告)号：US09637483B2
公开(公告)日：2017-05-02
申请号：US14779347
申请日：2014-03-27
发明人： Masato Yoshida , Hiroyuki Nagamiya , Yusuke Ohba , Masaki Seto , Takatoshi Yogo , Satoshi Sasaki , Norihito Tokunaga , Kazuyoshi Aso
IPC分类号： A61K31/437 , C07D401/14 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided is a compound or a salt thereof, which has an excellent JAK inhibitory action, and is useful as a prophylactic or therapeutic agent for autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's syndrome, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the present specification, or a salt thereof.
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公开(公告)号：US20150094296A1
公开(公告)日：2015-04-02
申请号：US14388452
申请日：2013-03-27
发明人： Tetsuya Tsukamoto , Yusuke Ohba , Takafumi Yukawa , Hiroyuki Nagamiya , Taku Kamei , Norihito Tokunaga , Morihisa Saitoh , Atsutoshi Okabe
IPC分类号： C07D403/04 , C07D401/14 , C07D413/14 , C07D491/107 , C07D403/14 , C07D405/14
CPC分类号： C07D403/04 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/107
摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供了一种用于预防或治疗自身免疫性疾病（例如牛皮癣，类风湿性关节炎，炎性肠病，干燥综合征，白塞病，多发性硬化，系统性红斑狼疮等）等，其具有优异的Tyk2 抑制作用。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US09085578B2
公开(公告)日：2015-07-21
申请号：US14379343
申请日：2013-02-19
发明人： Hiroyuki Nagamiya , Masato Yoshida , Masaki Seto , Shogo Marui , Tsuneo Oda , Yuji Ishichi , Hideo Suzuki , Tomokazu Kusumoto , Takatoshi Yogo , Chul Yun Rhim , Cheolhwan Yoon , Gil Nam Lee , Hyun Bin Kang , Kwang Ok Kim , Hye Sun Jeon
IPC分类号： C07D401/14 , A61K31/437 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供了一种用于预防或治疗自身免疫性疾病（例如牛皮癣，类风湿性关节炎，炎性肠病，干燥综合征，白塞病，多发性硬化，系统性红斑狼疮等）等，其具有优异的Tyk2 抑制作用。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US09187453B2
公开(公告)日：2015-11-17
申请号：US14388452
申请日：2013-03-27
发明人： Tetsuya Tsukamoto , Yusuke Ohba , Takafumi Yukawa , Hiroyuki Nagamiya , Taku Kamei , Norihito Tokunaga , Morihisa Saitoh
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , C07D403/04 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D491/107
CPC分类号： C07D403/04 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/107
摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US20150045349A1
公开(公告)日：2015-02-12
申请号：US14379343
申请日：2013-02-19
发明人： Hiroyuki Nagamiya , Masato Yoshida , Masaki Seto , Shogo Marui , Tsuneo Oda , Yuji Ishichi , Hideo Suzuki , Tomokazu Kusumoto , Takatoshi Yogo , Chul Yun Rhim , Cheolhwan Yoon , Gil Nam Lee , Hyun Bin Kang , Kwang Ok Kim , Hye Sun Jeon
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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