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公开(公告)号:US11584737B2
公开(公告)日:2023-02-21
申请号:US17042394
申请日:2019-03-28
发明人: Koji Ono , Masahiro Ito , Toshio Tanaka , Moriteru Asano , Takaharu Hirayama , Jun Fujimoto , Nobuki Sakauchi , Yasuhiro Hirata , Akinori Toita , Nao Morishita , Hironori Kokubo , Yasuhiro Imaeda , Hironobu Maezaki , Douglas Robert Cary , Ryo Mizojiri , Nobuo Cho , Hiroshi Banno , Hidekazu Tokuhara , Yasuyoshi Arikawa
IPC分类号: C07D401/14 , C07D403/14 , A61P35/00 , C07D213/84 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/10 , C07D487/10 , C07D495/10
摘要: Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号:US11459325B2
公开(公告)日:2022-10-04
申请号:US16961476
申请日:2019-01-30
发明人: Yuta Tanaka , Tomohiro Ohashi , Zenichi Ikeda , Yuta Tanaka , Florian Pünner , Takeshi Yamamoto , Keiko Kakegawa , Fumiaki Kikuchi , Nao Morishita , Takahito Kasahara , Masaki Seto , Minoru Nakamura , Kazuaki Takami , Masataka Murakami , Masaki Daini , Satoshi Mikami , Minoru Sasaki
IPC分类号: C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61P25/28
摘要: The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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