公开(公告)号：US11584737B2

公开(公告)日：2023-02-21

申请号：US17042394

申请日：2019-03-28

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Koji Ono ,  Masahiro Ito ,  Toshio Tanaka ,  Moriteru Asano ,  Takaharu Hirayama ,  Jun Fujimoto ,  Nobuki Sakauchi ,  Yasuhiro Hirata ,  Akinori Toita ,  Nao Morishita ,  Hironori Kokubo ,  Yasuhiro Imaeda ,  Hironobu Maezaki ,  Douglas Robert Cary ,  Ryo Mizojiri ,  Nobuo Cho ,  Hiroshi Banno ,  Hidekazu Tokuhara ,  Yasuyoshi Arikawa

IPC分类号： C07D401/14 ,  C07D403/14 ,  A61P35/00 ,  C07D213/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D471/10 ,  C07D487/10 ,  C07D495/10

摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US09745325B2

公开(公告)日：2017-08-29

申请号：US15304727

申请日：2015-04-16

申请人： Takeda Pharmaceutical Company Limited

发明人： Masanori Okaniwa ,  Hiroshi Banno ,  Takaharu Hirayama ,  Douglas Robert Cary ,  Koji Ono ,  Naoki Iwamura

IPC分类号： C07D513/04 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377

CPC分类号： C07D513/04 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377

摘要： The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound represented by formula (I) (wherein the symbols are as defined in the description) or a salt thereof.

公开(公告)号：US10981934B2

公开(公告)日：2021-04-20

申请号：US16663601

申请日：2019-10-25

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Youichi Kawakita ,  Takuto Kojima ,  Noriyuki Nii ,  Yoshiteru Ito ,  Nobuki Sakauchi ,  Hiroshi Banno ,  Xin Liu ,  Koji Ono ,  Keisuke Imamura ,  Shinichi Imamura

IPC分类号： A61K31/53 ,  C07D519/00 ,  A61K31/444 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/4985 ,  A61P35/00

摘要： Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].

公开(公告)号：US10577382B2

公开(公告)日：2020-03-03

申请号：US16094030

申请日：2017-04-27

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Youichi Kawakita ,  Takuto Kojima ,  Noriyuki Nii ,  Yoshiteru Ito ,  Nobuki Sakauchi ,  Hiroshi Banno ,  Xin Liu ,  Koji Ono ,  Keisuke Imamura ,  Shinichi Imamura

IPC分类号： C07D519/00 ,  A61K31/53 ,  A61P35/00

摘要： Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein].