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公开(公告)号：US10301292B2
公开(公告)日：2019-05-28
申请号：US15529816
申请日：2015-11-25
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Ryo Mizojiri , Hiroshi Banno , Moriteru Asano , Daisuke Tomita , Noriyuki Nii , Hironobu Maezaki , Michiko Tawada
IPC: C07D413/04 , C07D413/14 , A61K31/343 , A61K31/381 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/517 , A61K31/5377 , C07D231/56 , C07D333/56 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D263/54 , C07D498/04 , C07D307/81 , C07D263/57 , C12N15/09
Abstract: Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.
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公开(公告)号：US20180002322A1
公开(公告)日：2018-01-04
申请号：US15529816
申请日：2015-11-25
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Ryo Mizojiri , Hiroshi BANNO , Moriteru ASANO , Daisuke TOMITA , Noriyuki Nii , Hironobu MAEZAKI , Michiko TAWADA
IPC: C07D413/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D405/04 , C07D231/56 , C07D401/04 , C07D333/56 , C07D307/81 , C07D263/57 , C07D498/04 , C07D413/12
CPC classification number: C07D413/04 , A61K31/343 , A61K31/381 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/517 , A61K31/5377 , C07D231/56 , C07D263/54 , C07D263/57 , C07D307/81 , C07D333/56 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C12N15/09
Abstract: Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.
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公开(公告)号：US11584737B2
公开(公告)日：2023-02-21
申请号：US17042394
申请日：2019-03-28
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Koji Ono , Masahiro Ito , Toshio Tanaka , Moriteru Asano , Takaharu Hirayama , Jun Fujimoto , Nobuki Sakauchi , Yasuhiro Hirata , Akinori Toita , Nao Morishita , Hironori Kokubo , Yasuhiro Imaeda , Hironobu Maezaki , Douglas Robert Cary , Ryo Mizojiri , Nobuo Cho , Hiroshi Banno , Hidekazu Tokuhara , Yasuyoshi Arikawa
IPC: C07D401/14 , C07D403/14 , A61P35/00 , C07D213/84 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/10 , C07D487/10 , C07D495/10
Abstract: Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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Patent Agency Ranking
公开(公告)号：US09133129B2
公开(公告)日：2015-09-15
申请号：US14353622
申请日：2012-10-23
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC: A61K31/437 , C07D471/04 , C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/4439 , C07D413/04 , C07D498/04 , C07D307/80 , C07D235/18 , C07D263/57 , C07D513/04
CPC classification number: C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US10252997B2
公开(公告)日：2019-04-09
申请号：US15563128
申请日：2016-03-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Ryo Mizojiri , Moriteru Asano , Daisuke Tomita , Hiroshi Banno , Michiko Tawada , Noriyuki Nii , Krista E. Gipson , Hironobu Maezaki , Shuntarou Tsuchiya , Mayumi Imai , Yuichiro Amano
IPC: C07D213/65 , A61K31/165 , A61K31/167 , A61K31/277 , A61K31/381 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/451 , A61K31/454 , A61K31/4965 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , C07D213/75 , C07D213/81 , C07D231/12 , C07D333/20 , C07D401/04 , C07D237/14 , C07D239/34 , C07D409/04 , C07D413/04 , C07D241/18 , C07D417/04 , C07C233/18 , C07C233/47 , C07D261/08 , C07D263/32 , C07D263/42 , C07D207/08 , C07D207/12 , C07D277/34 , C07D211/44 , C07D213/643 , C07D213/69 , C07C233/25 , C07C255/54 , C07D211/46 , C07D213/74 , C07D401/12 , C12N9/99 , C12N15/09
Abstract: The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
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公开(公告)号：US20180079723A1
公开(公告)日：2018-03-22
申请号：US15563128
申请日：2016-03-30
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Ryo Mizojiri , Moriteru ASANO , Daisuke TOMITA , Hiroshi BANNO , Michiko TAWADA , Noriyuki NII , Krista E. GIPSON , Hironobu MAEZAKI , Shuntaro TSUCHIYA , Mayumi IMAI , Yuichiro AMANO
IPC: C07D213/65 , C07C233/25 , C07D401/12 , C07C255/54 , C07D213/69 , C07C233/18 , C07D263/42 , C07D263/32 , C07D413/04 , C07D239/34 , C07D241/18 , C07D277/34 , C07D231/12 , C07D207/12 , C07D261/08 , C07D417/04 , C07D237/14 , C07D211/46 , C07D213/74 , C07D213/81
CPC classification number: C07D213/65 , A61K31/165 , A61K31/167 , A61K31/277 , A61K31/381 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/451 , A61K31/454 , A61K31/4965 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , C07C233/18 , C07C233/25 , C07C233/47 , C07C255/54 , C07C2601/02 , C07C2601/14 , C07D207/08 , C07D207/12 , C07D211/44 , C07D211/46 , C07D213/643 , C07D213/69 , C07D213/74 , C07D213/75 , C07D213/81 , C07D231/12 , C07D237/14 , C07D239/34 , C07D241/18 , C07D261/08 , C07D263/32 , C07D263/42 , C07D277/34 , C07D333/20 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/04 , C12N9/99 , C12N15/09
Abstract: The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
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公开(公告)号：US09605000B2
公开(公告)日：2017-03-28
申请号：US14775265
申请日：2014-03-13
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Shizuo Kasai , Masaki Ogino , Ryo Mizojiri , Takeshi Yamasaki , Hideki Hirose , Nobuyuki Takakura , Tohru Yamashita , Sachie Morimoto , Takashi Nakahata , Asato Kina
IPC: C07D498/10 , A61P3/00 , A61K31/424
CPC classification number: C07D498/10
Abstract: Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification.
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公开(公告)号：US20140243310A1
公开(公告)日：2014-08-28
申请号：US14353622
申请日：2012-10-23
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC: C07D231/56 , C07D498/04 , C07D307/80 , C07D413/04 , C07D263/57 , C07D235/18
CPC classification number: C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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