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公开(公告)号：US10968231B2
公开(公告)日：2021-04-06
申请号：US16497141
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa , Satoshi Sasaki , Shigemitsu Matsumoto
IPC分类号： C07D491/052 , C07D211/22 , C07D401/12 , C07D401/14
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US09611244B2
公开(公告)日：2017-04-04
申请号：US15148210
申请日：2016-05-06
IPC分类号： C07D317/72 , C07C317/12 , C07D309/28 , C07C317/44 , C07C317/46
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
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公开(公告)号：US09533966B2
公开(公告)日：2017-01-03
申请号：US15175292
申请日：2016-06-07
IPC分类号： C07D317/72
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
摘要翻译： （其中，在说明书中更详细地说明每个符号）。
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公开(公告)号：US11186565B2
公开(公告)日：2021-11-30
申请号：US16499432
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Kazuaki Takami , Norihito Tokunaga , Tomohiro Okawa , Akito Shibuya , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa
IPC分类号： C07D401/12 , C07C59/72 , C07D211/22 , C07D213/64 , C07D401/10 , C07D401/14 , C07D413/10
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US20170066737A1
公开(公告)日：2017-03-09
申请号：US15356906
申请日：2016-11-21
发明人： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC分类号： C07D317/72 , C07C317/46 , C07D309/28 , C07C317/44
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: wherein, each symbol is explained in greater detail in the specification.
摘要翻译： 其中，在说明书中更详细地说明每个符号。
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公开(公告)号：US20160326133A1
公开(公告)日：2016-11-10
申请号：US15175292
申请日：2016-06-07
发明人： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC分类号： C07D317/72
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
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公开(公告)号：US10738004B2
公开(公告)日：2020-08-11
申请号：US16331962
申请日：2017-09-07
发明人： Toshitake Kobayashi , Morihisa Saitoh , Yasufumi Wada , Nobuyuki Negoro , Masashi Yamasaki , Takahiro Tanaka , Naomi Kitamoto
IPC分类号： C07C317/46 , A61K31/235 , A61P1/16 , A61P9/10 , A61P37/02 , A61P29/00 , A61P25/02 , A61P43/00
摘要： Provided is a compound, such as ethyl 6-((2-chloro-4-fluorobenzyl)sulfonyl) -3-hydroxycyclohex-1-ene-1-carboxylate or an optical isomer thereof, having a superior Toll-like receptor 4 (TLR4) signaling inhibitory action, which may be useful as a prophylactic or therapeutic drug for diseases such as autoimmune diseases and/or inflammatory diseases, or chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver failure, and ischemia reperfusion injury (IRI).
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公开(公告)号：US09828357B2
公开(公告)日：2017-11-28
申请号：US15356906
申请日：2016-11-21
发明人： Toshitake Kobayashi , Morihisa Saitoh , Yasufumi Wada , Hiroshi Nara , Nobuyuki Negoro , Taisuke Katoh , Masashi Yamasaki , Takahiro Tanaka , Naomi Kitamoto
IPC分类号： C07D317/72 , C07C317/12 , C07D309/28 , C07C317/44 , C07C317/46
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: wherein, each symbol is explained in greater detail in the specification.
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公开(公告)号：US20160326102A1
公开(公告)日：2016-11-10
申请号：US15148210
申请日：2016-05-06
发明人： Toshitake Kobayashi , Morihisa SAITOH , Yasufumi WADA , Hiroshi NARA , Nobuyuki NEGORO , Taisuke KATOH , Masashi YAMASAKI , Takahiro TANAKA , Naomi KITAMOTO
IPC分类号： C07C317/12 , C07D309/28 , C07D317/72
CPC分类号： C07D317/72 , C07C317/12 , C07C317/44 , C07C317/46 , C07C2601/16 , C07C2602/08 , C07D309/28
摘要： The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like.The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).
摘要翻译： （其中，在说明书中更详细地说明每个符号）。
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