公开(公告)号：US20170079915A1

公开(公告)日：2017-03-23

申请号：US15126334

申请日：2015-03-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yukihiro NOMURA ,  Yuki TSUSHIMA ,  Yutaka EBISAWA

IPC: A61K9/14 ,  B29B9/10 ,  B01J2/22 ,  A61K31/501

CPC classification number: A61K9/146 ,  A61K9/145 ,  A61K31/4422 ,  A61K31/501 ,  B01J2/22 ,  B29B9/10 ,  B29K2001/08 ,  B29K2105/0035

Abstract: A solid dispersion for achieving improved solubility and absorbability of a pharmaceutically active ingredient, which contains (1) an amorphous pharmaceutically active ingredient, (2) one or more substances selected from among methyl cellulose and organic acids and (3) an enteric base material. In cases where methyl cellulose is contained therein, the solid dispersion does not contain any water-soluble polymer other than methyl cellulose.

公开(公告)号：US20150110873A1

公开(公告)日：2015-04-23

申请号：US14583441

申请日：2014-12-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Masafumi MISAKI ,  Yuki TSUSHIMA ,  Masahiro NIWA

IPC: A61K9/20 ,  A61K31/495

CPC classification number: A61K9/2027 ,  A61K9/2018 ,  A61K9/2813 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2886 ,  A61K31/495

Abstract: The present invention relates to an enteric tablet with improved bioavailability, which is rapidly disintegrated after reaching the intestine to allow dissolution of the active ingredient, and which characteristically reduces the amount of talc to be used and is free of an alkali component.

Abstract translation: 本发明涉及具有改善的生物利用度的肠溶片剂，其在到达肠后快速崩解以允许活性成分溶解，并且其特征在于减少使用的滑石并且不含碱组分。