公开(公告)号：US20200000730A1

公开(公告)日：2020-01-02

申请号：US16432091

申请日：2019-06-05

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Ikuro YAMANE ,  Yukihiro NOMURA ,  Yutaka NISHIMOTO ,  Wataru HOSHINA

IPC: A61K9/20 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K31/519 ,  A61K9/28

Abstract: Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.

公开(公告)号：US20170079915A1

公开(公告)日：2017-03-23

申请号：US15126334

申请日：2015-03-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yukihiro NOMURA ,  Yuki TSUSHIMA ,  Yutaka EBISAWA

IPC: A61K9/14 ,  B29B9/10 ,  B01J2/22 ,  A61K31/501

CPC classification number: A61K9/146 ,  A61K9/145 ,  A61K31/4422 ,  A61K31/501 ,  B01J2/22 ,  B29B9/10 ,  B29K2001/08 ,  B29K2105/0035

Abstract: A solid dispersion for achieving improved solubility and absorbability of a pharmaceutically active ingredient, which contains (1) an amorphous pharmaceutically active ingredient, (2) one or more substances selected from among methyl cellulose and organic acids and (3) an enteric base material. In cases where methyl cellulose is contained therein, the solid dispersion does not contain any water-soluble polymer other than methyl cellulose.

公开(公告)号：US20180036250A1

公开(公告)日：2018-02-08

申请号：US15553852

申请日：2016-02-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Ikuro YAMANE ,  Yukihiro NOMURA ,  Yutaka NISHIMOTO ,  Wataru HOSHINA

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/519

CPC classification number: A61K9/2031 ,  A61K9/20 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2886 ,  A61K31/519 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.