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公开(公告)号：US20230063805A1
公开(公告)日：2023-03-02
申请号：US17846830
申请日：2022-06-22
发明人： Yuichi KAJITA , Yuhei MIYANOHANA , Tatsuki KOIKE , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D211/36 , C07D405/06 , A61P25/26 , C07D409/10 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20230042358A1
公开(公告)日：2023-02-09
申请号：US17413469
申请日：2019-12-11
发明人： Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Yasushi HATTORI , Norihito TOKUNAGA , Tsuneo ODA , Tohru MIYAZAKI , Dilhumar UYGHUR , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO , Koichiro FUKUDA , Yasuhisa KOHARA , Rei OKAMOTO , Taiichi OHRA , Naoki MIYAMOTO , Jun CHIBA , Yoshito TERAO , Masanori KAWASAKI
IPC分类号： C07D455/02 , A61P25/26 , C07D471/04 , C07D217/24 , C07D239/90 , C07D237/32 , C07D401/10 , C07D403/10 , C07D498/04 , C07D417/06 , C07D401/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20190040010A1
公开(公告)日：2019-02-07
申请号：US16052967
申请日：2018-08-02
发明人： Yuichi Kajita , Satoshi MIKAMI , Yuhei MIYANOHANA , Tatsuki KOIKE , Masaki DAINI , Norio OHYABU , Masaki OGINO , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D401/10 , C07D401/06 , C07D207/14 , C07D405/10 , C07D417/06 , C07D405/12 , C07D413/06 , C07D401/14 , C07D205/04 , C07D403/06 , C07D417/14 , A61P25/00
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20240360080A1
公开(公告)日：2024-10-31
申请号：US18520037
申请日：2023-11-27
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D207/14 , C07D403/06 , C07D407/08 , C07D417/06
CPC分类号： C07D207/14 , C07D403/06 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20210269420A1
公开(公告)日：2021-09-02
申请号：US17256330
申请日：2019-06-27
发明人： Tatsuhiko FUJIMOTO , Koichiro FUKUDA , Hiromichi SUGIMOTO , Kentaro RIKIMARU , Yoshihiro BANNO , Takahiro MATSUMOTO , Norihito TOKUNAGA , Yoshihide TOMATA , Yuji ISHICHI , Shogo MARUI , Tsuneo ODA , Tohru MIYAZAKI , Yasutaka HOASHI , Yasushi HATTORI , Yuichi KAJITA , Yuhei MIYANOHANA , Tatsuki KOIKE
IPC分类号： C07D401/14 , C07D405/14 , C07D211/56
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20210198240A1
公开(公告)日：2021-07-01
申请号：US16973320
申请日：2019-06-27
发明人： Tsuneo ODA , Yoshiteru ITO , Tohru MIYAZAKI , Kohei TAKEUCHI , Norihito TOKUNAGA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA , Yuichi KAJITA , Yuhei MIYANOHANA , Takahiro SUGIMOTO , Tatsuki KOIKE , Dilhumar UYGHUR
IPC分类号： C07D405/12 , C07D207/14 , C07D401/14 , C07D401/06 , C07D417/14 , C07D417/06 , C07D405/14 , C07D211/56 , C07D405/06 , C07D403/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20170253591A1
公开(公告)日：2017-09-07
申请号：US15510225
申请日：2015-09-10
发明人： Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Takashi IMADA , Mitsunori KONO , Ayumu SATO , Yoshihide TOMATA , Atsuko OCHIDA , Naoki ISHII , Yusuke SASAKI , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC分类号： C07D471/04 , C07D413/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D239/96 , C07D409/14 , C07D403/12 , C07D401/12 , C07D417/14 , C07D401/14 , C07D413/14
CPC分类号： C07D471/04 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P1/00 , A61P11/00 , C07D239/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
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公开(公告)号：US20160002169A1
公开(公告)日：2016-01-07
申请号：US14755439
申请日：2015-06-30
发明人： Satoshi YAMAMOTO , Junya SHIRAI , Tsuneo ODA , Mitsunori KONO , Atsuko OCHIDA , Takashi IMADA , Hidekazu TOKUHARA , Yoshihide TOMATA , Naoki ISHII , Michiko TAWADA , Yoshiyuki FUKASE , Tomoya YUKAWA , Shoji FUKUMOTO
IPC分类号： C07D217/26 , C07D491/056 , C07D491/048 , C07F7/08 , C07D471/04
CPC分类号： C07D217/26 , A61K31/4375 , A61K31/472 , A61K31/4741 , C07D217/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07F7/0812
摘要： The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
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公开(公告)号：US20150299188A1
公开(公告)日：2015-10-22
申请号：US14423310
申请日：2013-08-23
发明人： Masaki OGINO , Zenichi IKEDA , Jun FUJIMOTO , Yusuke OHBA , Naoki ISHII , Takuya FUJIMOTO , Tsuneo ODA , Naohiro TAYA , Toshiro YAMASHITA , Nobuyuki MATSUNAGA
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K9/2018 , A61K9/4858 , C07D239/80 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D417/12 , C07D487/04 , C07D513/04 , C07D519/00
摘要： Provided is a compound having a superior FLAP inhibitory action and useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, and a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present DESCRIPTION, or a salt thereof.
摘要翻译： 提供具有优异的FLAP抑制作用并可用作动脉硬化等的预防或治疗剂及其盐的化合物。 本发明涉及由下式表示的化合物，其中各符号如本说明书所定义，或其盐。
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公开(公告)号：US20230040770A1
公开(公告)日：2023-02-09
申请号：US17427490
申请日：2020-01-30
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Tatsuki KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D403/06 , C07D207/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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