公开(公告)号：US20170113224A1

公开(公告)日：2017-04-27

申请号：US15398518

申请日：2017-01-04

Applicant: TECAN TRADING AG

Inventor： Marc N. FEIGLIN

IPC: B01L3/00 ,  G01N27/447 ,  C12Q1/68 ,  B01F13/00 ,  B01L3/02 ,  B01L7/00

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: A cartridge has a container with at least one well, protrusions distributed on the container base side, and a flat polymer film having a lower surface and a hydrophobic upper surface kept at a distance (d) to the container base side by the protrusions. The container and the film are reversibly attachable to a liquid droplet manipulation instrument so that the lower surface of the film abuts at least one electrode array of the instrument. The container enables displacement of at least one liquid droplet from a well onto the hydrophobic upper surface of the flat polymer film and above the electrode array. The liquid droplet manipulation instrument comprises a control unit with a voltage control and an electrode selector for individually selecting each electrode of the electrode array and for providing the selected electrode with a voltage and thus controlling a guided movement of a liquid droplet on the hydrophobic upper surface of the flat polymer film by electrowetting. Also disclosed are a corresponding kit and method.

公开(公告)号：US20130270114A1

公开(公告)日：2013-10-17

申请号：US13900712

申请日：2013-05-23

Applicant: Tecan Trading AG

Inventor： Marc N. FEIGLIN

IPC: G01N27/447

Abstract: Digital microfluidics system manipulates samples in liquid droplets within disposable cartridges that have bottom layer, top layer, and gap between the bottom and top layers. The system has a base unit with cartridge accommodation sites and a central control unit for controlling selection of individual electrodes of electrode arrays and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the cartridges by electrowetting. The system further has board accommodation sites located at the cartridge accommodation sites that each can take up a swappable electrode board having an electrode array and electrical board contact elements individually connected to electrodes of the electrode array. Each board accommodation site has electrical base unit contact elements that are connected to the central control unit and that are configured to engage with the electrical board contact elements of a swappable electrode board that is placed at the board accommodation site.

Abstract translation: 数字微流体系统在一次性盒中的液滴中操作样品，其具有底层，顶层和底层和顶层之间的间隙。 该系统具有带有卡盘容纳位置的基座单元和用于控制电极阵列的各个电极的选择的中央控制单元，并且用于通过电润湿来为这些电极提供用于操纵墨盒内的液滴的各个电压脉冲。 该系统还具有位于盒容纳位置处的板容纳位置，每个可容纳具有电极阵列的可插拔电极板和分别连接到电极阵列的电极的电板接触元件。 每个电路板容纳部位具有连接到中央控制单元的电气基座单元接触元件，并且被配置为与放置在电路板接合位置的可插拔电极板的电路板接触元件接合。