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公开(公告)号：US20240359177A1
公开(公告)日：2024-10-31
申请号：US18763917
申请日：2024-07-03
发明人： Yann MARCY , Quentin LE MASNE , Kevin MARQ
IPC分类号： B01L3/00 , B01L9/00 , C12Q1/6844
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/527 , C12Q1/6844 , B01L2200/027 , B01L2200/16 , B01L2300/0654 , B01L2300/0819 , B01L2300/0848 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0478 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0644 , B01L2400/065 , B01L2400/0655
摘要： A cam-driven actuator for actuating valves of a microfluidic cartridge includes a plunger associated with each valve, a plunger guide plate having a plunger guide hole for each plunger, an actuating ball associated with each plunger and in contact with the associated plunger, a ball guide plate having a ball guide hole for each actuating ball; and a cam including a first surface and a cam recess. Each actuating ball is in contact with the cam and the cam is movable with respect to each actuating ball between (i) an engaged position at which the actuating ball is in contact with the first surface and the associated plunger is in an engaged position to close the associated valve, and (ii) a disengaged position at which the actuating ball is disposed within the cam recess and the associated plunger is in a disengaged position to open the associated valve.
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公开(公告)号：US12121902B2
公开(公告)日：2024-10-22
申请号：US17413039
申请日：2018-12-13
申请人： MGI Tech Co., Ltd.
发明人： Xing-Ye Cui , Zi-Hua Niu , Chu-Tian Xing , Jian Liu
CPC分类号： B01L9/52 , G01N35/10 , B01L2200/025 , B01L2300/0819
摘要： A portable sample loading device (1,4,7) include a base (11,41,71) and a fixing device (11,41,71) connected to the base (12,42,72). The base (12,42,72) can support a chip (2,5) and a sample loading connector (3,6). The fixing device (12,42,72) can detachably retain the chip (2,5) and the sample loading connector (3,6) on the base (11,41,71). The base (11,41,71) includes a front surface (110,410,710) and a back surface (111,411,711) opposite to the front surface (110,410,710). The front surface (110,410,710) includes a supporting surface for supporting the chip (2,5). A region of the supporting surface (112,412,712) corresponds to a sample inlet of the chip (2,5) is recessed toward the back surface (111,411,711) to form a receiving space (114,117,414,714) for receiving the sample loading connector (3,6). The receiving space (114,117,414,714) further defines a sample injection hole (115, 415,715) corresponding to the sample inlet of the chip (2,5).
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公开(公告)号：US12121895B2
公开(公告)日：2024-10-22
申请号：US17278243
申请日：2018-12-28
发明人： Shengqi Wang , Rui Xiao , Zhen Rong
IPC分类号： B01L3/00 , B01L7/00 , G01N35/10 , G01N33/569
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/00 , G01N35/10 , B01L2300/0819 , B01L2300/1805 , B01L2300/1894 , B01L2400/0478 , B01L2400/0666 , G01N33/56983
摘要： Biochip detection apparatus includes a cavity for carrying a test tube vial, the test tube vial being used for accommodating a sample to be detected and a biochip, the cavity having a temperature control function; a liquid storage device for storing liquid; a pumping device for pumping the liquid in the liquid storage device to the test tube vial, the pumping device being in fluid communication with a separation needle for injecting a mixed liquid into the test tube vial; an imaging device for monitoring the chip state in the test tube vial; and a data processing device configured to acquire hybridization results on the basis of information about a biochip state acquired by the imaging device.
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公开(公告)号：US20240302369A1
公开(公告)日：2024-09-12
申请号：US18006361
申请日：2021-07-23
发明人： Robert G. ULRICH , Mohan NATESAN
IPC分类号： G01N33/569 , B01L3/00 , G01N33/68
CPC分类号： G01N33/56983 , B01L3/502761 , G01N33/6854 , B01L2200/16 , B01L2300/046 , B01L2300/0819 , B01L2400/049 , G01N2333/165 , G01N2333/18
摘要： The present invention provides a system and methods for the detection of peptides from and antibodies against coronaviruses, filoviruses, flaviviruses, or combination thereof, in a sample. A method for detecting the presence of a coronavirus in a sample may comprise: collecting a small sample of a biological fluid from the test subject, adding sample to a viral test cassette, initiating sample processing by the assay cassette to incubate the diluted sample and developing reagents with an antibody microarray contained within the cassette, and results of the test are read by visual examination and process the results to determine if the subject is infected by a coronavirus.
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公开(公告)号：US20240286130A1
公开(公告)日：2024-08-29
申请号：US18587577
申请日：2024-02-26
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2300/0627 , B01L2300/0819 , B01L2300/168
摘要： A structured biochip may include a structured film disposed on a substrate, where the structured film includes a plurality of sensing regions spatially distributed across the substrate, and where the plurality of sensing regions provides spatially-varying optical characteristics across the substrate. The structured film may be functionalized with binding molecules configured to selectively bind with one or more analytes, where binding of the one or more analytes to the binding molecules generates an adlayer, and where a thickness of the adlayer impacts the spatially-varying optical characteristics of the plurality of sensing regions. At least one of a presence or a concentration of at least one of the one or more analytes may be determinable based on the spatially-varying optical characteristics of the plurality of sensing regions.
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公开(公告)号：US12048929B2
公开(公告)日：2024-07-30
申请号：US17393147
申请日：2021-08-03
发明人： Yu-Chen Chen , Han-Jung Liao , Kang-Yun Lee , Shu-Chuan Ho , Weilun Sun , Cheng-Hsien Liu
CPC分类号： B01L3/502753 , B01L3/502715 , C12M23/16 , C12M25/14 , C12M41/46 , C12M41/48 , C12N5/0068 , B01L2300/0645 , B01L2300/0819 , B01L2300/0883 , B01L2400/0424 , C12N2513/00
摘要： An array platform for three-dimensional cell culturing and drug testing and screening is disclosed. In the array platform, a hydrogel-cell mixture injection area is configured to inject a plurality of kinds of hydrogel-cell mixtures. Cell observation areas are connected to the hydrogel-cell mixture injection area. Electrodes are disposed under the cell observation areas and automatic cell quantification and three-dimensional cell co-arrangement of the plurality of kinds of hydrogel-cell mixtures in the cell observation areas through the electrodes to imitate a structure of body's tissues. A drug injection area is configured to inject a plurality of kinds of drugs. Drug combination generators respectively correspond to the cell observation areas and are connected to the drug injection area. Each drug combination generator has a microfluidic channel structure and configured to generate drug combinations according to the plurality of kinds of drugs.
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公开(公告)号：US12044614B2
公开(公告)日：2024-07-23
申请号：US17589507
申请日：2022-01-31
发明人： Kalyan Handique , Austin Payne , Vishal Sharma , Kyle Gleason , Priyadarshini Gogoi , Karthik Ganesan , Brian Boniface , Will Chow
IPC分类号： G01N15/14 , B01L3/00 , B01L3/02 , C12M1/00 , G01N1/20 , G01N1/28 , G01N1/40 , G01N15/1433 , G01N35/00 , G01N35/10 , G06V10/141 , G06V10/145 , G06V10/147 , G06V20/69 , G01N15/00 , G01N15/01 , G01N15/10
CPC分类号： G01N15/1484 , B01L3/502715 , B01L3/502761 , C12M47/04 , G01N1/20 , G01N1/28 , G01N1/40 , G01N1/405 , G01N1/4077 , G01N15/1433 , G01N35/00029 , G01N35/1011 , G06V10/141 , G06V10/145 , G06V10/147 , G06V20/69 , B01L3/021 , B01L3/502746 , B01L2200/0652 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0848 , B01L2300/0877 , B01L2300/168 , B01L2400/086 , G01N15/01 , G01N2015/1006 , G01N2015/149 , G01N2035/00158 , G01N2035/1039
摘要： A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
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公开(公告)号：US12038430B2
公开(公告)日：2024-07-16
申请号：US17046099
申请日：2019-04-25
发明人： Alan S. Verkman , Byung-Ju Jin , Sujin Lee
CPC分类号： G01N33/5008 , B01L3/502715 , B01L2200/027 , B01L2300/0819 , B01L2300/0861 , G01N2800/382
摘要： Provided herein are methods and systems for screening a candidate agent to determine whether the candidate agent modulates an activity of cultured cells. Compositions for screening a candidate agent are also provided herein.
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公开(公告)号：US20240219287A1
公开(公告)日：2024-07-04
申请号：US18557517
申请日：2022-04-29
发明人： Jiarong Hong , Ruichen He
IPC分类号： G01N15/1434 , B01L3/00 , G01N15/01 , G06V10/143 , G06V10/26 , G06V10/774 , G06V10/82 , G06V20/69
CPC分类号： G01N15/1434 , B01L3/502715 , G01N15/01 , G06V10/143 , G06V10/26 , G06V10/774 , G06V10/82 , G06V20/693 , G06V20/695 , G06V20/698 , B01L2300/0819 , B01L2300/168
摘要： A system and method for characterizing biological particles. A multi-spectral digital inline holographic includes a computing system, a camera and a light source having a. coherent multi-spectral beam of light. Tire light source illuminates a sample having one or more biological particles and the camera captures holograms produced by interference of (i) light from the coherent multi-spectral beam of light that was scattered by the sample with (ii) light from the coherent multi-spectral beam of light that was not scattered, by the sample, the captured holograms including holograms from two or more spectral bands. The computing system applies a machine learning model to the captured holograms to extract features of the biological particles m the sample from the captured holograms.
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公开(公告)号：US12017222B2
公开(公告)日：2024-06-25
申请号：US17465732
申请日：2021-09-02
发明人： Marco Cereda , Lillo Raia , Danilo Pirola
IPC分类号： B01L3/00 , A61B5/15 , A61B5/154 , B01F33/30 , B01F33/40 , B01F33/452 , B01L9/00 , C12M3/06 , C12Q1/6806 , C12Q1/6844
CPC分类号： B01L3/502753 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/154 , B01F33/30 , B01F33/406 , B01F33/452 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/5029 , B01L3/508 , B01L3/5082 , B01L3/52 , B01L3/527 , B01L9/527 , C12M23/16 , A61B5/150389 , A61B5/150503 , A61B5/150732 , B01L3/5023 , B01L3/502707 , B01L3/50825 , B01L3/523 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/0642 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/044 , B01L2300/0609 , B01L2300/0681 , B01L2300/08 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/087 , B01L2300/12 , B01L2300/16 , B01L2300/1827 , B01L2400/04 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , C12Q1/6806 , C12Q1/6844 , C12Q1/6806 , C12Q2565/629 , C12Q1/6844 , C12Q2565/629
摘要： An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.
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