公开(公告)号：US20210077520A1

公开(公告)日：2021-03-18

申请号：US17042441

申请日：2019-03-27

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Shulamit LEVENBERG ,  Shaowei GUO ,  Daniel OFFEN ,  Nisim PERETS

IPC: A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/113

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

公开(公告)号：US20240384228A1

公开(公告)日：2024-11-21

申请号：US18549537

申请日：2022-03-08

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Shulamit LEVENBERG ,  Shaowei GUO ,  Barak ZOHAR ,  Lior DEBBI

IPC: C12N5/071

Abstract: The present invention provides stem cells-derived extracellular vesicles (EVs) characterized by upregulation and/or downregulation of specific proteins. Composition comprising the EVs. and their use in the treatment of diseases and disorders associated with the upregulated proteins are also provided.

公开(公告)号：US20210189329A1

公开(公告)日：2021-06-24

申请号：US17194972

申请日：2021-03-08

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED

Inventor： Shulamit LEVENBERG ,  Shaowei Guo ,  Barak Zohar

IPC: C12N5/071

Abstract: The present invention provides methods and systems for enhanced production and/or secretion of extracellular vesicles from at least one three-dimensional porous scaffold having a population of stem cells cultured thereon, utilizing various shear stress conditions on a variety of stem cells.