公开(公告)号：US20240423976A1

公开(公告)日：2024-12-26

申请号：US18749968

申请日：2024-06-21

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

Inventor： Vibhuti AGRAHARI ,  Neeraj S. THAKUR

IPC: A61K31/495 ,  A61K9/06 ,  A61K31/05 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34

Abstract: A method and composition for mitigating or reducing drug-induced ototoxicity or drug-induced hearing loss in a subject in need of such treatment, comprising: providing a drug delivery system which releases a therapeutic drug upon exposure to reactive oxygen species, wherein the drug delivery system comprises a thermoresponsive hydrogel containing therapeutic drug-loaded crosslinked hybrid nanoparticles and provides sustained therapeutic drug release. The crosslinked hybrid nanoparticles within which the therapeutic drug is loaded may comprise 10,12-Pentacosadiynoic acid (PCDA) and polypropylene sulfide-polyethylene glycol monomethyl ether (PPS-mPEG). The drug-induced ototoxicity or hearing loss may be caused by cisplatin or other platinum-based drugs.