专利检索 ap:("THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM") AND inv:"Cang Chen" 第 1 页

1.

发明授权
Methods and compositions for treating chronic granulomatous disease 有权

公开(公告)号：US11738053B2

公开(公告)日：2023-08-29

申请号：US16329915

申请日：2017-09-01

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Senlin Li , Robert A Clark , Cang Chen , Yang Li

IPC分类号： A01N63/00 , C12N15/63 , C07H21/04 , A61K35/28 , A61K38/19 , A01K67/027 , C12N15/86

CPC分类号： A61K35/28 , A01K67/0276 , A61K38/193 , C12N15/86 , A01K2227/105 , A01K2267/0306 , C12N2740/16043

摘要： The invention relates to a method of treating chronic granulomatous disease through Hematopoietic stem cell (HSC) transplantation. The method comprises the steps of administering stem cell mobilization agent to human such that the target stem cell population migrates from host niches into the subject's blood. The target stem cells are removed from blood and administering the therapeutic stem cells to human and said therapeutic stem cells are engineered to express gp91phox. The steps are repeated multiple times i.e. at least four times. The mobilization agents used in the invention are granulocyte-colony stimulating factor and AMD3100. The method of HSC transplantation is effective in treatment of chronic granulomatous disease.