公开(公告)号：US09539283B2

公开(公告)日：2017-01-10

申请号：US14425375

申请日：2013-09-04

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Charles Y. C. Pak ,  Khashayar Sakhaee ,  Orson W. Moe

IPC: A61K33/06 ,  A23L1/304 ,  A61K31/19 ,  A61K33/08 ,  A23L2/52 ,  A61K33/10 ,  A23L2/40

CPC classification number: A61K33/06 ,  A23K20/24 ,  A23L2/40 ,  A23L2/52 ,  A23L33/16 ,  A23L33/30 ,  A23V2002/00 ,  A23V2200/00 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/194 ,  A61K33/08 ,  A61K33/10 ,  A23V2200/306 ,  A23V2250/032 ,  A23V2250/1578 ,  A23V2250/161 ,  A61K2300/00

Abstract: Disclosed is an effervescent preparation of calcium and magnesium with additional citric acid in a defined ratio. Also disclosed is the use of these compositions to raise cardioprotective citrate and magnesium in serum to help prevent heart attacks from calcium supplements, and to provide bioavailable calcium and magnesium to prevent osteoporosis-related fractures and low blood magnesium from the use of proton pump inhibitors.

Abstract translation: 公开了具有规定比例的额外柠檬酸的钙和镁的泡腾制剂。 还公开了使用这些组合物来提高血清中的心脏保护性柠檬酸盐和镁，以帮助防止钙补充剂的心脏病发作，并提供生物可利用的钙和镁以防止使用质子泵抑制剂引起骨质疏松症相关骨折和低血镁。

公开(公告)号：US10092593B2

公开(公告)日：2018-10-09

申请号：US15288210

申请日：2016-10-07

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Charles Y. C. Pak ,  Khashayar Sakhaee ,  Orson W. Moe

IPC: A61K33/06 ,  A61K31/19 ,  A23K20/24 ,  A23L33/16 ,  A23L2/40 ,  A23L2/52 ,  A61K33/08 ,  A61K33/10 ,  A23L33/00 ,  A61K9/00 ,  A61K9/08 ,  A61K31/194

Abstract: Disclosed is an effervescent preparation of calcium and magnesium with additional citric acid in a defined ratio. Also disclosed is the use of these compositions to raise cardioprotective citrate and magnesium in serum to help prevent heart attacks from calcium supplements, and to provide bioavailable calcium and magnesium to prevent osteoporosis-related fractures and low blood magnesium from the use of proton pump inhibitors.