公开(公告)号：US20230255951A1

公开(公告)日：2023-08-17

申请号：US18055045

申请日：2022-11-14

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Maithili P. DALVI ,  Elisabeth D. MARTINEZ ,  John D. MINNA ,  Juan BAYO-FINA ,  Amit DAS

IPC: A61K31/444 ,  A61K45/06 ,  A61K31/00 ,  A61K31/44 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282 ,  A61K31/337 ,  A61K31/55 ,  A61N5/10

CPC classification number: A61K31/444 ,  A61K45/06 ,  A61K31/00 ,  A61K31/44 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282 ,  A61K31/337 ,  A61K31/55 ,  A61N5/10

Abstract: Disclosed are methods for the use of Jumonji C demethylase inhibitors for the radiosensitization of cancers cells and the treatment and prevention of chemotherapy resistance in cancer.