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公开(公告)号：US20240150752A1
公开(公告)日：2024-05-09
申请号：US18280803
申请日：2022-03-08
Inventor： Ralf KITTLER , John D. MINNA , Paul M. YENERALL
IPC: C12N15/10 , C12N15/86 , C12Q1/6886
CPC classification number: C12N15/1079 , C12N15/1086 , C12N15/86 , C12Q1/6886 , C12N2740/15022 , C12N2740/15043 , C12Q2600/106 , C12Q2600/156
Abstract: Disclosures herein are directed to methods and compositions for the detection of and screening for mutations that convey phenotypic properties in a protein such as, for example, drug-resistance. Embodiments of the present disclosure include lentiviral-based compositions for transferring a gene encoding a protein of interest into a target cell for screening according to methods disclosed herein.
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公开(公告)号：US20230255951A1
公开(公告)日：2023-08-17
申请号：US18055045
申请日：2022-11-14
Inventor： Maithili P. DALVI , Elisabeth D. MARTINEZ , John D. MINNA , Juan BAYO-FINA , Amit DAS
IPC: A61K31/444 , A61K45/06 , A61K31/00 , A61K31/44 , A61P35/00 , A61K33/243 , A61K31/282 , A61K31/337 , A61K31/55 , A61N5/10
CPC classification number: A61K31/444 , A61K45/06 , A61K31/00 , A61K31/44 , A61P35/00 , A61K33/243 , A61K31/282 , A61K31/337 , A61K31/55 , A61N5/10
Abstract: Disclosed are methods for the use of Jumonji C demethylase inhibitors for the radiosensitization of cancers cells and the treatment and prevention of chemotherapy resistance in cancer.
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公开(公告)号：US20240141330A1
公开(公告)日：2024-05-02
申请号：US18409612
申请日：2024-01-10
Inventor： Ralf KITTLER , John D. MINNA , Paul M. YENERALL
CPC classification number: C12N15/1082 , G01N33/5011
Abstract: Disclosures herein are directed to methods and compositions for the detection of and screening for mutations that convey phenotypic properties in a protein such as, for example, drug-resistance. Embodiments of the present disclosure include lentiviral-based compositions for enhanced mutagenesis and screening of genes encoding proteins of interest that confer drug resistance according to methods disclosed herein.
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