公开(公告)号：US20190060446A1

公开(公告)日：2019-02-28

申请号：US16081911

申请日：2017-03-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming GAO ,  Zhijian CHEN ,  Min LUO ,  Zhaohui WANG ,  Hua WANG ,  Haocheng CAI ,  Gang HUANG ,  Yang-Xin FU

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.