公开(公告)号：US20210333263A1

公开(公告)日：2021-10-28

申请号：US16333164

申请日：2017-09-12

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Zhaohui WANG ,  Min LUO ,  Qi WEI ,  Gang HUANG

IPC: G01N33/50 ,  G01N33/542 ,  C09K11/07 ,  G01N21/64

Abstract: Provided herein are compounds of the formula: (I) wherein the variables are defined herein, which may be used as redox-activatable sensors. In some aspects, the compounds are fluorescence sensors which are activated by the redox state of the cell. Also provided herein are methods of using these compounds to image the cellular environment or the delivery of macromolecules to a cell.

公开(公告)号：US20190060446A1

公开(公告)日：2019-02-28

申请号：US16081911

申请日：2017-03-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming GAO ,  Zhijian CHEN ,  Min LUO ,  Zhaohui WANG ,  Hua WANG ,  Haocheng CAI ,  Gang HUANG ,  Yang-Xin FU

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.