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公开(公告)号：US20170143852A1
公开(公告)日：2017-05-25
申请号：US15369701
申请日：2016-12-05
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , G01N33/58 , C08F8/30 , G01N21/64 , C08F8/32 , C08F8/34 , C09B69/10 , G01N33/84 , C08F8/42
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20200087451A1
公开(公告)日：2020-03-19
申请号：US16570337
申请日：2019-09-13
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20190060446A1
公开(公告)日：2019-02-28
申请号：US16081911
申请日：2017-03-02
Inventor： Jinming GAO , Zhijian CHEN , Min LUO , Zhaohui WANG , Hua WANG , Haocheng CAI , Gang HUANG , Yang-Xin FU
IPC: A61K39/39 , A61K39/00 , A61K9/51 , A61K39/145
Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.
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公开(公告)号：US20180369424A1
公开(公告)日：2018-12-27
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20210333263A1
公开(公告)日：2021-10-28
申请号：US16333164
申请日：2017-09-12
Inventor： Jinming GAO , Zhaohui WANG , Min LUO , Qi WEI , Gang HUANG
IPC: G01N33/50 , G01N33/542 , C09K11/07 , G01N21/64
Abstract: Provided herein are compounds of the formula: (I) wherein the variables are defined herein, which may be used as redox-activatable sensors. In some aspects, the compounds are fluorescence sensors which are activated by the redox state of the cell. Also provided herein are methods of using these compounds to image the cellular environment or the delivery of macromolecules to a cell.
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Patent Agency Ranking
公开(公告)号：US20190071380A1
公开(公告)日：2019-03-07
申请号：US16063347
申请日：2016-12-16
Inventor： Jinming GAO , Yuliang LIU , Qi WEI , Xinpeng MA , Gang HUANG
IPC: C07C50/32 , C07C311/21 , C07C233/33 , C07C225/30 , C07D295/116 , C07C233/42 , C07C233/91 , C07C311/08 , A61P35/00
CPC classification number: C07C50/32 , A61K9/0019 , A61K9/5123 , A61K9/5146 , A61P35/00 , C07C205/46 , C07C225/30 , C07C233/18 , C07C233/31 , C07C233/33 , C07C233/42 , C07C233/91 , C07C271/30 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/51 , C07C2601/14 , C07C2602/10 , C07D295/116 , C07D317/70
Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.
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公开(公告)号：US20250009656A1
公开(公告)日：2025-01-09
申请号：US18710555
申请日：2022-11-15
Inventor： Jinming GAO , Gang HUANG , Zhichen SUN , Qiang FENG , Wei LI
Abstract: Ultra pH sensitive (UPS) micelles encapsulating cytokines are provided that provide lower toxicity and higher efficacy compositions and methods for treating cancer with those compositions.
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公开(公告)号：US20240115741A1
公开(公告)日：2024-04-11
申请号：US18449675
申请日：2023-08-14
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N21/64 , G01N33/58 , G01N33/84
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20230416457A1
公开(公告)日：2023-12-28
申请号：US18159084
申请日：2023-01-24
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
CPC classification number: C08G65/007 , A61K49/0054 , G01N33/582 , G01N21/643 , G01N21/6456 , G01N33/84 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20200333357A1
公开(公告)日：2020-10-22
申请号：US16763518
申请日：2018-11-13
Inventor： Jinming GAO , Michael A. WHITE , Chensu WANG , Yang LI , Bruce POSNER , Gang HUANG
IPC: G01N33/68 , C08F293/00 , A61K49/00
Abstract: The present disclosure is directed to a nanotechnology-enabled screening strategy to identify small molecule TFEB agonists that shift maturation of autophagosomes to degradative autolysosomes.
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