公开(公告)号：US20240043483A1

公开(公告)日：2024-02-08

申请号：US18266712

申请日：2021-12-21

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Marc DIAMOND ,  Victor MANON ,  Jaime VAQUER-ALICEA ,  Brian HITT

IPC: C07K14/47 ,  C12N15/63 ,  G01N33/68 ,  G01N33/50

CPC classification number: C07K14/4711 ,  C12N15/63 ,  G01N33/6896 ,  G01N33/5058

Abstract: The present disclosure provides biosensor cells and methods of use thereof. The disclosure provides, for example, methods of measuring a titer of or of detecting a seed tau protein in a sample, methods of detecting Alzheimer's disease (AD), or a neurodegenerative tauopathy disease or condition linked to tau protein aggregation, and methods for the identification of putative tau protein aggregation inhibitors or modulators.