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公开(公告)号：US10888545B2
公开(公告)日：2021-01-12
申请号：US15885273
申请日：2018-01-31
发明人： Gregory R. Thatcher , Debra Tonetti , Mary Ellen Molloy , Bradley Michalsen , Zihui Qin , Rui Xiong
IPC分类号： G01N33/574 , A61K31/381 , C07D333/64
摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20170100371A1
公开(公告)日：2017-04-13
申请号：US15264407
申请日：2016-09-13
IPC分类号： A61K31/381 , G01N33/574
CPC分类号： A61K31/381 , C07D333/64 , G01N33/57496 , G01N2333/91205 , G01N2800/52
摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20180214414A1
公开(公告)日：2018-08-02
申请号：US15885273
申请日：2018-01-31
IPC分类号： A61K31/381 , G01N33/574
CPC分类号： A61K31/381 , C07D333/64 , G01N33/57496 , G01N2333/91205 , G01N2800/52
摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US09895348B2
公开(公告)日：2018-02-20
申请号：US15264407
申请日：2016-09-13
IPC分类号： A61K31/381 , G01N33/574
CPC分类号： A61K31/381 , C07D333/64 , G01N33/57496 , G01N2333/91205 , G01N2800/52
摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20190224346A1
公开(公告)日：2019-07-25
申请号：US16254017
申请日：2019-01-22
发明人： Stephen DiMagno , Gregory R. Thatcher , Debra Tonetti , Rui Xiong , Bao Hu
IPC分类号： A61K51/04 , A61B6/03 , A61B6/00 , C07D333/64 , A61P35/00
摘要： Disclosed herein are 18F-labeled compounds and compositions thereof. Also disclosed are methods of imaging estrogen receptor expressing tissues, or methods of identifying cancer lesions using these compounds.
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6.发明授权公开(公告)号：US09475791B2
公开(公告)日：2016-10-25
申请号：US14438326
申请日：2013-10-24
IPC分类号： C07D333/64 , A61K31/381 , G01N33/574
CPC分类号： A61K31/381 , C07D333/64 , G01N33/57496 , G01N2333/91205 , G01N2800/52
摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
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7.发明申请公开(公告)号：US20150291552A1
公开(公告)日：2015-10-15
申请号：US14438326
申请日：2013-10-24
IPC分类号： C07D333/64 , G01N33/574
CPC分类号： A61K31/381 , C07D333/64 , G01N33/57496 , G01N2333/91205 , G01N2800/52
摘要： Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了治疗雌激素相关医学病症的方法。 治疗方法可以包括向需要这种治疗的受试者施用包含治疗有效量的至少一种式（I）化合物或其药学上可接受的盐的组合物。
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