公开(公告)号：US20190255046A1

公开(公告)日：2019-08-22

申请号：US15998610

申请日：2017-02-15

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： Alan KOZIKOWSKI ,  Sida SHEN ,  Joel BERGMAN ,  Irina GAISINA

IPC: A61K31/498 ,  A61P35/00 ,  A61P37/00 ,  A61P25/28 ,  C07D241/44 ,  A61K31/5415 ,  C07D279/16 ,  A61K31/47 ,  C07D215/08

Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.