公开(公告)号：US20240343697A1

公开(公告)日：2024-10-17

申请号：US18618511

申请日：2024-03-27

Applicant: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation ,  The Board of Trustees of the University of Illinois

Inventor： Alejandro VILLAGRA ,  Alan P. KOZIKOWSKI ,  Sida SHEN

IPC: C07D261/18 ,  A61K45/06 ,  A61P35/00 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04

CPC classification number: C07D261/18 ,  A61P35/00 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  A61K45/06

Abstract: The present disclosure provides compounds represented by Formula I:






and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

公开(公告)号：US20190255046A1

公开(公告)日：2019-08-22

申请号：US15998610

申请日：2017-02-15

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： Alan KOZIKOWSKI ,  Sida SHEN ,  Joel BERGMAN ,  Irina GAISINA

IPC: A61K31/498 ,  A61P35/00 ,  A61P37/00 ,  A61P25/28 ,  C07D241/44 ,  A61K31/5415 ,  C07D279/16 ,  A61K31/47 ,  C07D215/08

Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.

公开(公告)号：US20230250054A1

公开(公告)日：2023-08-10

申请号：US18002952

申请日：2021-06-25

Applicant: The Board of Trustees of the University of Illinois ,  THE GEORGE WASHINGTON UNIVERSITY

Inventor： Sida SHEN ,  Alejandro VILLAGRA ,  Alan KOZIKOWSKI

IPC: C07C275/40 ,  C07F5/02 ,  A61K39/395 ,  A61P35/00 ,  A61K31/17 ,  A61K31/69

CPC classification number: C07C275/40 ,  C07F5/025 ,  A61K39/3955 ,  A61P35/00 ,  A61K31/17 ,  A61K31/69

Abstract: The present disclosure provides methods, pharmaceutical compositions, and kits comprising histone deacetylase (HD AC) inhibitors of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, L1, L2, m, n, p, X, Y, and Z are as defined in the specification, including methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy in a subject.

公开(公告)号：US20220153709A1

公开(公告)日：2022-05-19

申请号：US17590503

申请日：2022-02-01

Applicant: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation ,  The Board of Trustees of the University of Illinois

Inventor： Alejandro VILLAGRA ,  Alan P. KOZIKOWSKI ,  Sida SHEN

IPC: C07D261/18 ,  A61P35/00 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04

Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.