专利检索 ap:("THE BRIGHAM AND WOMEN'S HOSPITAL, INC." OR "UNIVERSITY OF OSLO") AND inv:"Jan Terje ANDERSEN" 第 1 页

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发明申请
BLOCKADE OF ALPHAFETOPROTEIN (AFP) INTERACTIONS WITH BETA2-MICROGLOBULIN ASSOCIATED MOLECULES 审中-公开

公开(公告)号：US20190201496A1

公开(公告)日：2019-07-04

申请号：US16333918

申请日：2017-09-14

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , UNIVERSITY OF OSLO

发明人： Richard S. BLUMBERG , Michal PYZIK , Amit GANDHI , Inger SANDLIE , Kine Marita Knudsen SAND , Jan Terje ANDERSEN

IPC分类号： A61K38/38 , C07K14/47 , C12P21/02 , A61P37/06 , C07K14/765

CPC分类号： A61K38/38 , A61P37/06 , C07K14/47 , C07K14/4715 , C07K14/70539 , C07K14/765 , C07K16/2833 , C07K19/00 , C12P21/02

摘要： Provided herein, in some aspects, are compositions and methods to inhibit AFP interactions with β2M and/or Class I-related molecule interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate AFP interactions with β2M and/or Class I-related molecule in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels is desired to increase immunosuppression or enhance organ regeneration.