公开(公告)号：US09890127B2

公开(公告)日：2018-02-13

申请号：US14775354

申请日：2014-03-11

申请人： THE BROAD INSTITUTE, INC. ,  DANA FARBER CANCER INSTITUTE, INC.

发明人： Timothy A. Lewis ,  Benito Munoz ,  Lucian De Waal ,  Heidi Greulich ,  Matthew Meyerson ,  Lara Nicole Gechijian

IPC分类号： A61K31/535 ,  C07D237/04 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

CPC分类号： C07D237/04 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

摘要： Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.

公开(公告)号：US20200061050A9

公开(公告)日：2020-02-27

申请号：US16198589

申请日：2018-11-21

申请人： The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Michel Weiwer ,  Versha Banerji

IPC分类号： A61K31/4745 ,  C07D471/04 ,  A61K31/4747 ,  C07D471/10

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer.

公开(公告)号：US20150313890A1

公开(公告)日：2015-11-05

申请号：US14799281

申请日：2015-07-14

申请人： The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Michel Weiwer ,  Versha Banerji

IPC分类号： A61K31/4745 ,  A61K31/4747

CPC分类号： A61K31/4745 ,  A61K31/4747 ,  C07D471/04 ,  C07D471/10

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

摘要翻译： 本发明提供式I化合物，其药学上可接受的盐及其药物组合物。 本发明的化合物可用于抑制激酶（例如GSK3（例如GSK3α或GSK3和bgr））或CK1）活性。 本发明进一步提供了使用本文所述化合物治疗激素介导的疾病如神经疾病，精神疾病，代谢紊乱和癌症的方法。

公开(公告)号：US09096594B2

公开(公告)日：2015-08-04

申请号：US14052661

申请日：2013-10-11

申请人： The Broad Institute, Inc. ,  The General Hospital Corporation ,  Dana-Farber Cancer Institute, Inc.

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michel Weiwer ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Versha Banerji

IPC分类号： C07D471/04 ,  C07D471/10

CPC分类号： A61K31/4745 ,  A61K31/4747 ,  C07D471/04 ,  C07D471/10

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

摘要翻译： 本发明提供式I化合物，其药学上可接受的盐及其药物组合物。 本发明的化合物可用于抑制激酶（例如GSK3（例如GSK3α或GSK3和bgr））或CK1）活性。 本发明进一步提供了使用本文所述化合物治疗激素介导的疾病如神经疾病，精神疾病，代谢紊乱和癌症的方法。

公开(公告)号：US11052080B2

公开(公告)日：2021-07-06

申请号：US16198589

申请日：2018-11-21

申请人： The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Michel Weiwer ,  Versha Banerji

IPC分类号： C07D471/04 ,  C07D471/10 ,  A61K31/4745 ,  A61K31/4747

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

公开(公告)号：US20220160702A1

公开(公告)日：2022-05-26

申请号：US17344830

申请日：2021-06-10

申请人： The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Michel Weiwer ,  Versha Banerji

IPC分类号： A61K31/4745 ,  C07D471/04 ,  C07D471/10 ,  A61K31/4747

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

公开(公告)号：US20190175584A1

公开(公告)日：2019-06-13

申请号：US16198589

申请日：2018-11-21

申请人： The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Michel Weiwer ,  Versha Banerji

IPC分类号： A61K31/4745 ,  C07D471/04 ,  A61K31/4747 ,  C07D471/10

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer.

公开(公告)号：US10137122B2

公开(公告)日：2018-11-27

申请号：US14799281

申请日：2015-07-14

申请人： The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation

发明人： Florence Fevrier Wagner ,  Jennifer Q. Pan ,  Sivaraman Dandapani ,  Andrew Germain ,  Edward Holson ,  Benito Munoz ,  Partha P. Nag ,  Michael C. Lewis ,  Stephen J. Haggarty ,  Joshua A. Bishop ,  Kimberly Stegmaier ,  Michel Weiwer ,  Versha Banerji

IPC分类号： A61K31/4745 ,  C07D471/04 ,  A61K31/4747 ,  C07D471/10

摘要： The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.

公开(公告)号：US20160016913A1

公开(公告)日：2016-01-21

申请号：US14775354

申请日：2014-03-11

申请人： THE BROAD INSTITUTE, INC. ,  DANA FARBER CANCER INSTITUTE INC.

发明人： Timothy A. Lewis ,  Benito Munoz ,  Lucian De Waal ,  Heidi Greulich ,  Matthew Meyerson ,  Lara Nicole Gechijian

IPC分类号： C07D237/04 ,  C07D401/10 ,  C07D413/10 ,  C07D403/10

CPC分类号： C07D237/04 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

摘要： Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.

摘要翻译： 公开了可以特别用于治疗癌症的化合物，例如哒嗪酮。

公开(公告)号：US20180244629A1

公开(公告)日：2018-08-30

申请号：US15874500

申请日：2018-01-18

申请人： The Broad Institute, Inc. ,  Dana Farber Cancer Institute, Inc.

发明人： Timothy A. Lewis ,  Benito Munoz ,  Lucian De Waal ,  Heidi Greulich ,  Matthew Meyerson ,  Lara Nicole Gechijian

IPC分类号： C07D237/04 ,  C07D413/10 ,  C07D403/10 ,  C07D401/10

CPC分类号： C07D237/04 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

摘要： Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.