公开(公告)号：US11492670B2

公开(公告)日：2022-11-08

申请号：US15298895

申请日：2016-10-20

申请人： THE BROAD INSTITUTE, INC. ,  DANA-FARBER CANCER INSTITUTE, INC. ,  INSTITUTO CARLOS SLIM DE LA SALUD, A.C.

发明人： William C. Hahn ,  Andrew Aguirre ,  April Cook ,  Glenn Cowley ,  Robin Meyers ,  David E. Root ,  Aviad Tsherniak ,  Barbara Weir ,  Francisca Vazquez

IPC分类号： C12Q1/68 ,  C07K1/00 ,  C12Q1/6886 ,  A61K38/46 ,  A61K45/06 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  A61K48/00 ,  B82Y5/00

摘要： The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.

公开(公告)号：US20170114413A1

公开(公告)日：2017-04-27

申请号：US15298895

申请日：2016-10-20

申请人： THE BROAD INSTITUTE INC. ,  DANA-FARBER CANCER INSTITUTE, INC.

发明人： William C. Hahn ,  Andrew Aguirre ,  April Cook ,  Glenn Cowley ,  Robin Meyers ,  David E. Root ,  Aviad Tsherniak ,  Barbara Weir ,  Francisca Vazquez

IPC分类号： C12Q1/68 ,  C12N15/113 ,  A61K38/46 ,  A61K45/06 ,  C12N9/22 ,  C12N9/96

CPC分类号： C12Q1/6886 ,  A61K38/465 ,  A61K45/06 ,  A61K48/00 ,  B82Y5/00 ,  C12N9/22 ,  C12N9/96 ,  C12N15/1135 ,  C12N2320/34 ,  C12N2740/15043 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.