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公开(公告)号：US20230192855A1
公开(公告)日：2023-06-22
申请号：US17870010
申请日：2022-07-21
发明人： Frederick W. ALT , Ming TIAN , Hwei-Ling CHENG
CPC分类号： C07K16/2818 , A61K39/001111 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/565
摘要： Described herein are novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein antibody-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating cancer by administering the disclosed antibody reagents.
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2.发明申请公开(公告)号：US20190390260A1
公开(公告)日：2019-12-26
申请号：US16481964
申请日：2018-02-13
发明人： Frederick W. ALT , Jiazhi HU , Sherry LIN , Zhou DU , Yu ZHANG , Huan CHEN
IPC分类号： C12Q1/6827 , C12Q1/6869 , G16B30/00 , C12Q1/6858
摘要： Described herein are methods and assays for detection of recombination and/or rearrangement events in a cell. In some embodiments, the methods and/or assays relate to Linear Amplification Mediated (LAM)-PCR. In some embodiments, the recombination event is a V(D)J recombination event.
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公开(公告)号：US20210238312A1
公开(公告)日：2021-08-05
申请号：US16973125
申请日：2019-06-10
发明人： Frederick W. ALT , Suvi JAIN , Zhaoqing BA , Ming TIAN
IPC分类号： C07K16/46 , A01K67/027 , C12N15/85 , C12N5/0735
摘要： Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
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4.发明公开公开(公告)号：US20240352154A1
公开(公告)日：2024-10-24
申请号：US18607961
申请日：2024-03-18
发明人： Frederick W. ALT , Suvi JAIN , Zhaoqing BA , Ming TIAN
IPC分类号： C07K16/46 , A01K67/0278 , C12N5/0735 , C12N15/85
CPC分类号： C07K16/461 , A01K67/0278 , C12N5/0606 , C12N15/8509 , A01K2207/15 , A01K2217/072 , A01K2227/105 , C07K2317/10
摘要： Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
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公开(公告)号：US20240294641A1
公开(公告)日：2024-09-05
申请号：US18005286
申请日：2021-07-13
发明人： Frederick W. ALT , Ming TIAN , Hwei-Ling CHENG
CPC分类号： C07K16/2818 , A61K47/6849 , C07K2317/21 , C07K2317/24 , C07K2317/565
摘要： The technology described herein is directed to novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein are antibody-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating an autoimmune or auto-inflammatory disorder by administering the disclosed antibody reagents.
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6.发明公开公开(公告)号：US20230298702A1
公开(公告)日：2023-09-21
申请号：US18129274
申请日：2023-03-31
发明人： Frederick W. ALT , Jiazhi HU , Sherry LIN , Zhou DU , Yu ZHANG , Huan CHEN
IPC分类号： G16B30/10 , G16B30/00 , C12Q1/6827 , C12Q1/6858 , C12Q1/6869 , C12Q1/686 , C12Q1/6855
CPC分类号： G16B30/10 , G16B30/00 , C12Q1/6827 , C12Q1/6858 , C12Q1/6869 , C12Q1/686 , C12Q1/6855 , C12Q2549/119
摘要： Described herein are methods and assays for detection of recombination and/or rearrangement events in a cell. In some embodiments, the methods and/or assays relate to Linear Amplification Mediated (LAM)-PCR. In some embodiments, the recombination event is a V(D)J recombination event.
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公开(公告)号：US20200181265A1
公开(公告)日：2020-06-11
申请号：US16608275
申请日：2018-05-01
发明人： Frederick W. ALT , Ming TIAN , Hwei-Ling CHENG
IPC分类号： C07K16/28
摘要： Described herein are novel anti-PD1 antibody reagents (e.g., antibodies, antigen-binding fragments thereof, and/or chimeric antigen receptors). Also described herein anti-body-drug conjugates or kits comprising the disclosed antibody reagents, as well as methods of treating cancer by administering the disclosed antibody reagents.
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