公开(公告)号：US20220095949A1

公开(公告)日：2022-03-31

申请号：US17429078

申请日：2020-02-06

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Daniela S. Allende ,  Federico N. Aucejo ,  Daniel M. Rotroff

IPC: A61B5/08 ,  A61B5/00 ,  G01N33/00 ,  G01N33/497

Abstract: A method for diagnosing a subject with one or more of hepatocellular carcinoma (HCC), chronic liver disease, colorectal liver metastases (CRLM), and pulmonary hypertension is described. The method includes obtaining a breath sample from a subject, analyzing the breath sample obtained from the subject to determine one or more breath metabolite abundance values, inputting one or more of the breath metabolite abundance values into a machine-learning-model, and assigning a clinical parameter to the subject representing the likelihood that the subject has one or more of HCC, chronic liver disease, CRLM, and pulmonary hypertension.