公开(公告)号：US10935552B2

公开(公告)日：2021-03-02

申请号：US15737187

申请日：2016-06-24

申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Benzhong Tang ,  Engui Zhao ,  Chen Gui ,  Meijuan Jiang ,  Haiqin Deng ,  Wai Tung Leung ,  Zhiming Wang ,  Yueyue Zhao ,  Tsz Kin Kwok ,  Lucia Viglianti ,  Ni Xie

IPC分类号： C09K11/06 ,  G01N33/58 ,  C08G65/00 ,  A61K49/00 ,  A61K41/00 ,  A61K31/4706 ,  A61K31/47 ,  A61K33/22 ,  A61K31/5375 ,  A61K31/695 ,  C09B23/04 ,  C09B26/02 ,  C09B57/00

摘要： The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.