公开(公告)号：US10196698B2

公开(公告)日：2019-02-05

申请号：US15598684

申请日：2017-05-18

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Srinivasan Yegnasubramanian ,  G. Steven Bova ,  Martin Aryee ,  William B. Isaacs ,  William G. Nelson

IPC分类号： C12Q1/6855 ,  C12Q1/6886

摘要： The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.

公开(公告)号：US20180100196A1

公开(公告)日：2018-04-12

申请号：US15598684

申请日：2017-05-18

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Srinivasan Yegnasubramanian ,  G. Steven Bova ,  Martin Aryee ,  William B. Isaacs ,  William G. Nelson

IPC分类号： C12Q1/6886 ,  C12Q1/6855

CPC分类号： C12Q1/6886 ,  C12Q1/6855 ,  C12Q2600/154 ,  C12Q2537/164 ,  C12Q2565/501 ,  C12Q2565/531

摘要： The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.

公开(公告)号：US20140274767A1

公开(公告)日：2014-09-18

申请号：US14162180

申请日：2014-01-23

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Srinivasan Yegnasubramanian ,  G. Steven Bova ,  Martin Aryee ,  William B. Isaacs ,  William G. Nelson

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6855 ,  C12Q2600/154 ,  C12Q2537/164 ,  C12Q2565/501 ,  C12Q2565/531

摘要： The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.

摘要翻译： 本发明涉及癌症领域。 更具体地，本发明提供了可用于评估前列腺癌的方法和组合物。 在一个具体的实施方案中，本发明人已经开发并应用了一种能够同时进行基因组（拷贝数）和表观遗传学（总甲基化（TM））和等位基因特异性甲基化（ASM）交替的基因组大规模分析的新技术和相关计算方法。 称为MBD-SNP，使用甲基结合结构域多肽具有亲和力富集或甲基化基因组DNA片段。