公开(公告)号：US11679157B2

公开(公告)日：2023-06-20

申请号：US17008495

申请日：2020-08-31

申请人： THE OHIO STATE UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Susan R. Mallery ,  Peter E. Larsen ,  Gary D. Stoner ,  Steven P. Schwendeman ,  Kashappa-Goud Desai

IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K31/07 ,  A61K9/70 ,  A61K47/32 ,  A61K47/24 ,  A61K47/28

CPC分类号： A61K47/10 ,  A61K9/006 ,  A61K9/0056 ,  A61K9/7007 ,  A61K31/07 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32

摘要： Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.

公开(公告)号：US20210052732A1

公开(公告)日：2021-02-25

申请号：US17008495

申请日：2020-08-31

申请人： THE OHIO STATE UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Susan R. Mallery ,  Peter E. Larsen ,  Gary D. Stoner ,  Steven P. Schwendeman ,  Kashappa-Goud Desai

IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K31/07 ,  A61K9/70 ,  A61K47/32 ,  A61K47/24 ,  A61K47/28

摘要： Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.

公开(公告)号：US20140056949A1

公开(公告)日：2014-02-27

申请号：US13885436

申请日：2011-11-15

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE OHIO STATE UNIVERSITY

发明人： Susan R. Mallery ,  Peter E. Larsen ,  Gary D. Stoner ,  Steven P. Schwendeman ,  Kashappa-Goud Desai

IPC分类号： A61K47/10 ,  A61K47/28 ,  A61K47/24 ,  A61K9/00

摘要： Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.

摘要翻译： 描述了用于化学预防口腔癌和癌前病变的制剂以及制备制剂的方法。

公开(公告)号：US11033496B2

公开(公告)日：2021-06-15

申请号：US16494995

申请日：2018-03-16

申请人： OHIO STATE INNOVATION FOUNDATION ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Susan R. Mallery ,  Joerg Lahann

IPC分类号： A61K36/73 ,  A61K47/62 ,  A61K47/69 ,  A61K9/16 ,  A61K9/00 ,  A61K9/06 ,  A61K31/167 ,  A61K31/198 ,  A61K39/395

摘要： Disclosed herein are nanoparticle compositions and methods of use such as for chemoprevention of cancer, for example oral squamous cell carcinoma (OSCC). The nanoparticle composition comprises a Janus particle comprising at least two chemopreventive agents, wherein at least one of the chemopreventive agents is selected from freeze-dried black raspberries (BRB), a synthetic vitamin A analogue, N-acetylcysteine (NAC), and an anti-interleukin 6 agent. Methods for improving oral health comprising administering to a subject the nanoparticle compositions are also disclosed.