公开(公告)号：US11149025B2

公开(公告)日：2021-10-19

申请号：US16790287

申请日：2020-02-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Csaba J. Peto ,  David Jablons ,  Hassan Lemjabbar-Alaoui

IPC: C07D403/04 ,  A61K31/502 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

Abstract: This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

公开(公告)号：US11072600B2

公开(公告)日：2021-07-27

申请号：US16310606

申请日：2017-06-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ATLASMEDX, INC.

Inventor： Csaba J. Peto ,  David M. Jablons ,  Tsze Tsang ,  Hassan Lemjabbar-Alaoui

IPC: C07D403/10 ,  A61P35/00 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D471/04

Abstract: The application relates to phthalazine derivatives of formula (I) which are inhibitors of PARP1, PARP2 and/or tubulin and thus useful for the treatment of cancer. Also disclosed are pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

公开(公告)号：US10562886B2

公开(公告)日：2020-02-18

申请号：US15574101

申请日：2016-05-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Csaba J. Peto ,  David Jablons ,  Hassan Lemjabbar-Alaoui

IPC: C07D403/04 ,  C07D403/14 ,  C07D401/14 ,  A61P35/00

Abstract: This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

公开(公告)号：US12145925B2

公开(公告)日：2024-11-19

申请号：US17376577

申请日：2021-07-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ATLASMEDX, INC.

Inventor： Csaba J. Peto ,  David M. Jablons ,  Tsze Tsang ,  Hassan Lemjabbar-Alaoui

IPC: C07D403/10 ,  A61P35/00 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D471/04

Abstract: The application relates to phthalazine derivatives of formula (I) which are inhibitors of PARP1, PARP2 and/or tubulin and thus useful for the treatment of cancer. Also disclosed are pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

公开(公告)号：US11708352B2

公开(公告)日：2023-07-25

申请号：US17502954

申请日：2021-10-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Csaba J. Peto ,  David Jablons ,  Hassan Lemjabbar-Alaoui

IPC: C07D403/04 ,  A61K31/502 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D403/04 ,  A61K31/502 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

Abstract: This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.