公开(公告)号：US20200163966A1

公开(公告)日：2020-05-28

申请号：US16625075

申请日：2018-06-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Thomas G. GRAEBER ,  Jennifer TSOI ,  Antoni RIBAS ,  Lidia ROBERT ,  Nicolaos PALASKAS

IPC: A61K31/517 ,  A61K35/17 ,  A61K31/437 ,  C07K16/28

Abstract: The current methods and compositions provide for a novel therapeutic method for treating patients diagnosed with melanoma, especially those that have become resistant to certain other therapies. Accordingly, certain aspects of the disclosure relate to a method for treating melanoma in a subject, the method comprising administering a composition comprising a ferroptosis-inducing agent or other dedifferentiated melanoma-targeting agent to the subject.