公开(公告)号：US20200163966A1

公开(公告)日：2020-05-28

申请号：US16625075

申请日：2018-06-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Thomas G. GRAEBER ,  Jennifer TSOI ,  Antoni RIBAS ,  Lidia ROBERT ,  Nicolaos PALASKAS

IPC: A61K31/517 ,  A61K35/17 ,  A61K31/437 ,  C07K16/28

Abstract: The current methods and compositions provide for a novel therapeutic method for treating patients diagnosed with melanoma, especially those that have become resistant to certain other therapies. Accordingly, certain aspects of the disclosure relate to a method for treating melanoma in a subject, the method comprising administering a composition comprising a ferroptosis-inducing agent or other dedifferentiated melanoma-targeting agent to the subject.

公开(公告)号：US20250154510A1

公开(公告)日：2025-05-15

申请号：US18949317

申请日：2024-11-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Thomas G. GRAEBER ,  Chia-Chin CHEN ,  Owen WITTE ,  Jung Wook PARK

IPC: C12N15/113 ,  A61K45/06 ,  A61N5/10

Abstract: The current disclosure is centered on the hypothesis that a better understanding of the neuroendocrine transdifferentiation (NEtD) process will provide therapeutic targets for inhibiting this transition and thus improving standard of care therapies. Accordingly, the current disclosure provides for a method for treating cancer in a subject, the method comprising administering an inhibitor of a gene, wherein the gene comprises one or more of tenascin C (TNC), advillin (AVIL), S100A7, PPARG, LOX lysyl oxidase, KLF5, APOBEC2, FOSL1, FOXM1, hedgehog, RELA, p65, IKK complex, JAK, STAT, TFAP4, geminin, OCA-1, OCA-2, Nf-kB, Nf-kB family and associated regulators, angiogenesis regulators such as BMX kinase, TEK kinase, periostin (POSTN), and VEGF family, stress genes, such as the JUN/FOS family, a gene from the S100 family, and cell state regulators such as ASCL1, POU2F3, NEUROD1, ASCL2, and YAP1.

公开(公告)号：US20220244263A1

公开(公告)日：2022-08-04

申请号：US17613881

申请日：2020-05-28

Applicant: The Regents of the University of California

Inventor： Thomas G. GRAEBER ,  Nikolas G. BALANIS ,  Katherine M. SHEU ,  Owen N. WITTE ,  Favour ESEDEBE ,  Jung Wook PARK

IPC: G01N33/574 ,  A61K45/06

Abstract: The current disclosure provides for methods of identifying and treating small cell neuroendocrine (SCN) tumors and small-round-blue cell tumor (SRBCT). Aspects of the disclosure relate to a method comprising measuring the level of expression of one or more biomarkers from Tables 1-3 in a biological sample from a cancer patient. Further aspects relate to a method for treating small cell neuroendocrine (SCN) cancer or small-round-blue cell tumor (SRBCT) in a patient comprising administering a cancer treatment to the patient, wherein the cancer treatment is a treatment selected from Table 4A, 4B, or combinations of treatments from Table 4A and/or 4B.