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公开(公告)号：US12083162B2
公开(公告)日：2024-09-10
申请号：US17208228
申请日：2021-03-22
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang
CPC classification number: A61K38/1796 , A61K9/127 , A61K47/6901
Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.
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公开(公告)号：US11357736B2
公开(公告)日：2022-06-14
申请号：US16779070
申请日：2020-01-31
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Zhiqing Pang , Ronnie H. Fang , Che-Ming Jack Hu
Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.
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公开(公告)号：US20210299217A1
公开(公告)日：2021-09-30
申请号：US17208228
申请日：2021-03-22
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Weiwei Gao , Ronnie H. Fang
Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.
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公开(公告)号：US20200222334A1
公开(公告)日：2020-07-16
申请号：US16779070
申请日：2020-01-31
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Zhiqing Pang , Ronnie H. Fang , Che-Ming Jack Hu
Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.
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5.发明授权公开(公告)号：US10285952B2
公开(公告)日：2019-05-14
申请号：US15000110
申请日：2016-01-19
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu
IPC: A61K9/00 , A61K9/51 , A61K9/50 , A61K35/17 , A61K35/18 , A61K35/19 , A61K31/4709 , A61K49/00 , G01N33/569 , G01N33/58
Abstract: Provided are methods, combinations and pharmaceutical compositions for treating or preventing an infection in a subject using a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane configured for adhesion of a pathogen that causes said infection. Exemplary infection includes infection caused by a virus, bacterium, fungus, or protozoan.
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Patent Agency Ranking
公开(公告)号：US10098839B2
公开(公告)日：2018-10-16
申请号：US15126342
申请日：2015-03-20
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Weiwei Gao , Jonathan Copp
IPC: A61K9/16 , A61K9/06 , A61K9/51 , A61K38/17 , A61K35/17 , A61K35/18 , A61K35/19 , A61K35/58 , A61K35/63 , A61K45/06 , A61K31/49 , A61L26/00 , A61K9/00 , A61L27/52 , A61L27/54 , A61K9/50
Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
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公开(公告)号：US20130122056A1
公开(公告)日：2013-05-16
申请号：US13673171
申请日：2012-11-09
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Santosh Aryal , Che-Ming Hu
IPC: A61K9/14 , A61K31/7048 , A61K31/555 , A61K47/48 , A61K31/7068
Abstract: The present teachings include ratiometric combinatorial drug delivery including nanoparticles, multi-drug conjugates, pharmaceutical compositions, methods of producing such compositions and methods of using such compositions, including in the treatment of diseases and conditions using drug combinations.
Abstract translation: 本教导包括比例式组合药物递送，包括纳米颗粒，多药物缀合物，药物组合物，生产此类组合物的方法和使用这些组合物的方法，包括在使用药物组合治疗疾病和病症时。
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公开(公告)号：US20250049715A1
公开(公告)日：2025-02-13
申请号：US18814200
申请日：2024-08-23
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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公开(公告)号：US20250017860A1
公开(公告)日：2025-01-16
申请号：US18814271
申请日：2024-08-23
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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公开(公告)号：US12097290B2
公开(公告)日：2024-09-24
申请号：US13827906
申请日：2013-03-14
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
CPC classification number: A61K9/148 , A61K39/001102 , A61K39/085 , A61K39/39 , A61K45/06 , A61K2039/55555 , A61K2039/80
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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