公开(公告)号：US09649358B2

公开(公告)日：2017-05-16

申请号：US14362891

申请日：2012-12-10

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Paul Lu ,  Mark H. Tuszynski

IPC分类号： A61K38/18 ,  A61K35/30

CPC分类号： A61K38/185 ,  A61K35/30 ,  A61K38/18 ,  A61K2300/00

摘要： Methods for inducing non-embryonic lesioned central nervous system neurons to survive, integrate, extend axons over long distances, induce intra-lesion ingrowth of neurons into the lesion from host tissue and form synapses in vivo. Pluripotent neural stem cells are grafted into the lesioned CNS tissue within a tissue adhesive suspension, optionally in the presence of growth factors. No modification of the neuronal regenerative inhibitory environment of the CNS is necessary.

公开(公告)号：US20140308256A1

公开(公告)日：2014-10-16

申请号：US14362891

申请日：2012-12-12

申请人： The Regents of the University of California

发明人： Paul Lu ,  Mark H. Tuszynski

IPC分类号： A61K38/18 ,  A61K35/30

CPC分类号： A61K38/185 ,  A61K35/30 ,  A61K38/18 ,  A61K2300/00

摘要： Methods for inducing non-embryonic lesioned central nervous system neurons to survive, integrate, extend axons over long distances, induce intra-lesion ingrowth of neurons into the lesion from host tissue and form synapses in vivo. Pluripotent neural stem cells are grafted into the lesioned CNS tissue within a tissue adhesive suspension, optionally in the presence of growth factors. No modification of the neuronal regenerative inhibitory environment of the CNS is necessary.

摘要翻译： 诱导非胚胎损伤的中枢神经系统神经元生存，整合，长距离延伸的轴突的方法，诱导神经元内的病变向内生长进入宿主组织的病变，并在体内形成突触。 多能神经干细胞可任选地在生长因子存在下移植到组织粘附性悬浮液内的病变CNS组织中。 不需要对CNS的神经元再生抑制环境进行修饰。