公开(公告)号：US20210316265A1

公开(公告)日：2021-10-14

申请号：US17178866

申请日：2021-02-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yuting Tang ,  Herbert Scher ,  Tina Jeoh Zicari

IPC: B01J13/10 ,  B01J13/04

Abstract: An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. The one-step spray drying process utilizes formulations of a first ionic polymer, a second ionic polymer with an isoelectric point (pI2) or acid dissociation constant (pKa2) that is greater than the isoelectric point (pI1) or acid dissociation constant (pKa1) of the first ionic polymer and a volatile base or volatile acid. Volatilization of the volatile base or acid of the spray formulation changes the pH of the solution and changes the charge of the second ionic polymer initiating electrostatic interactions with the first ionic polymer through complex coacervation. Microcapsules formed by the complex coacervation process can stabilize bioactive components as well as control the release of the bioactive components for a variety of applications.

公开(公告)号：US11612870B2

公开(公告)日：2023-03-28

申请号：US17178866

申请日：2021-02-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yuting Tang ,  Herbert Scher ,  Tina Jeoh Zicari

IPC: B01J13/10 ,  B01J13/04

Abstract: An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. The one-step spray drying process utilizes formulations of a first ionic polymer, a second ionic polymer with an isoelectric point (pI2) or acid dissociation constant (pKa2) that is greater than the isoelectric point (pI1) or acid dissociation constant (pKa1) of the first ionic polymer and a volatile base or volatile acid. Volatilization of the volatile base or acid of the spray formulation changes the pH of the solution and changes the charge of the second ionic polymer initiating electrostatic interactions with the first ionic polymer through complex coacervation. Microcapsules formed by the complex coacervation process can stabilize bioactive components as well as control the release of the bioactive components for a variety of applications.