公开(公告)号：US12018135B2

公开(公告)日：2024-06-25

申请号：US17336766

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Herbert B. Scher ,  Scott Strobel ,  Tina Jeoh Zicari ,  Dana Wong

IPC: C08J3/24 ,  B01J13/04 ,  B01J13/14 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095 ,  C08K5/5357

CPC classification number: C08J3/24 ,  B01J13/043 ,  B01J13/14 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095 ,  C08K5/5357 ,  C08J2305/04 ,  C08J2305/08 ,  C08K2003/162

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

公开(公告)号：US20220105487A1

公开(公告)日：2022-04-07

申请号：US17501745

申请日：2021-10-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Scott Strobel ,  Herbert B. Scher ,  Tina Jeoh Zicari

IPC: B01J13/14 ,  C08L5/04 ,  C08L3/06 ,  C08K5/09 ,  B01J13/04 ,  C08K3/28

Abstract: Systems and methods are provided for microencapsulating oxygen sensitive cargo such as polyunsaturated fatty acids and other oils by spray drying with an in situ internal gelation mechanism achieving cross-linking of polymers during the process, which is well-suited for industrial scale-up. Spray drying formulations of a mixture of an immiscible hydrophobic cargo and an emulsifier of a hydrophobically modified hydrophilic polymer with a suspension of a multivalent ion cross-linkable polymer, at least one acid, at least one volatile base and at least one salt of a multivalent ion can be adapted to provide control over particle size, degree of crosslinking, enteric release of cargo and shelf life. The methods produce microcapsules that enhance the shelf life of lipophilic bioactives while providing a mechanism of gastrointestinal delivery.

公开(公告)号：US11612870B2

公开(公告)日：2023-03-28

申请号：US17178866

申请日：2021-02-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yuting Tang ,  Herbert Scher ,  Tina Jeoh Zicari

IPC: B01J13/10 ,  B01J13/04

Abstract: An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. The one-step spray drying process utilizes formulations of a first ionic polymer, a second ionic polymer with an isoelectric point (pI2) or acid dissociation constant (pKa2) that is greater than the isoelectric point (pI1) or acid dissociation constant (pKa1) of the first ionic polymer and a volatile base or volatile acid. Volatilization of the volatile base or acid of the spray formulation changes the pH of the solution and changes the charge of the second ionic polymer initiating electrostatic interactions with the first ionic polymer through complex coacervation. Microcapsules formed by the complex coacervation process can stabilize bioactive components as well as control the release of the bioactive components for a variety of applications.

公开(公告)号：US20220025132A1

公开(公告)日：2022-01-27

申请号：US17336766

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Herbert B. Scher ,  Scott Strobel ,  Tina Jeoh Zicari ,  Dana Wong

IPC: C08J3/24 ,  B01J13/04 ,  B01J13/14 ,  C08K5/5357 ,  C08K3/16 ,  C08K3/28 ,  C08K5/095

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

公开(公告)号：US20210316265A1

公开(公告)日：2021-10-14

申请号：US17178866

申请日：2021-02-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yuting Tang ,  Herbert Scher ,  Tina Jeoh Zicari

IPC: B01J13/10 ,  B01J13/04

Abstract: An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. The one-step spray drying process utilizes formulations of a first ionic polymer, a second ionic polymer with an isoelectric point (pI2) or acid dissociation constant (pKa2) that is greater than the isoelectric point (pI1) or acid dissociation constant (pKa1) of the first ionic polymer and a volatile base or volatile acid. Volatilization of the volatile base or acid of the spray formulation changes the pH of the solution and changes the charge of the second ionic polymer initiating electrostatic interactions with the first ionic polymer through complex coacervation. Microcapsules formed by the complex coacervation process can stabilize bioactive components as well as control the release of the bioactive components for a variety of applications.

公开(公告)号：US20170333360A1

公开(公告)日：2017-11-23

申请号：US15615520

申请日：2017-06-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K38/38 ,  A61K47/30 ,  B01J13/04 ,  C08J3/24 ,  C08J3/12 ,  A61K38/47 ,  A61K9/16

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

公开(公告)号：US09700519B2

公开(公告)日：2017-07-11

申请号：US14288110

申请日：2014-05-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Tina Jeoh Zicari ,  Herbert B. Scher ,  Monica C. Santa-Maria ,  Scott Strobel

IPC: A61K9/50 ,  A61K31/734 ,  A61K47/30 ,  A61K9/16 ,  B01J13/04 ,  C08J3/12 ,  C08J3/24 ,  A61K38/38 ,  A61K38/47

CPC classification number: A61K9/5036 ,  A61K9/1694 ,  A61K9/5089 ,  A61K38/385 ,  A61K38/47 ,  A61K47/30 ,  B01J13/043 ,  B01J13/046 ,  C08J3/122 ,  C08J3/24 ,  C08J2305/04 ,  C08J2305/06 ,  C08J2389/00 ,  C12Y302/01004 ,  C12Y302/01008

Abstract: Microencapsulation of bioactive and chemical cargo in a stable, cross-linked polymer matrix is presented that results in small particle sizes and is easily scaled-up for industrial applications. A formulation of a salt of an acid soluble multivalent ion, an acid neutralized with a volatile base and one or more monomers that cross-link in the presence of multivalent ions is atomized into droplets. Cross-linking is achieved upon atomization where the volatile base is vaporized resulting in a reduction of the pH of the formulation and the temporal release of multivalent ions from the salt that cross-link the monomers forming a capsule. The incorporation of additional polymers or hydrophobic compounds in the formulation allows control of hydration properties of the particles to control the release of the encapsulated compounds. The operational parameters can also be controlled to affect capsule properties such as particle-size and particle-size distribution.

公开(公告)号：US20160289780A1

公开(公告)日：2016-10-06

申请号：US15090898

申请日：2016-04-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ASPECT AI LTD.

Inventor： Maria Cardona ,  Robert Louis Powell, III ,  Michael John McCarthy ,  Tina Jeoh Zicari ,  Emilio Javier Tozzi

IPC: C12Q3/00 ,  C12P19/02 ,  C12P19/14 ,  G01N11/04 ,  G01N24/08

CPC classification number: C12Q3/00 ,  C12M45/09 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  G01N11/04 ,  G01N24/085 ,  G01N24/088 ,  G01R33/563

Abstract: The present disclosure is generally related a method for the liquefaction of high-solids biomass substrates. Particularly, biomass can be added to a reactor until a pressure drop, measured inline, reaches the maximum system limitations. A commercial enzyme mixture (specific for the particular type of biomass to be processed) may then be added to the biomass, forming a slurry. The pressure may be continuously monitored and when the pressure drop reaches a steady state (which can be determined by little or no change in pressure drop for several minutes), more biomass may then be added until the high pressure limit of the pump system is reached again. The method can be repeated until the desired quantity of biomass is processed.

Abstract translation: 本公开通常涉及用于液化高固体生物质基质的方法。 特别地，可以将生物质加入到反应器中，直到在线测量的压降达到最大系统限制。 然后可以向生物质中加入商业酶混合物（特定于待处理的特定类型的生物质），形成浆料。 可以连续监测压力，并且当压降达到稳定状态（其可以通过很少或没有压力下降几分钟来确定）时，可以加入更多的生物质，直到达到泵系统的高压极限 再次。 可以重复该方法，直到处理所需量的生物量。