专利检索 ap:("THE REGENTS OF THE UNIVERSITY OF CALIFORNIA" OR "CHARITE-UNIVERSITATSMEDIZIN BERLIN" OR "MT. SINAI HOSPITAL") AND inv:"Alexander Brandt" 第 1 页

1.

发明申请
N-Acetyl Glucosamine as a Biomarker of MS Disease Course 审中-公开

公开(公告)号：US20180003717A1

公开(公告)日：2018-01-04

申请号：US15547496

申请日：2016-01-29

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHARITE-UNIVERSITATSMEDIZIN BERLIN , MT. SINAI HOSPITAL

发明人： Michael Demetriou , Alexander Brandt , Paul Friedmann , James Dennis

IPC分类号： G01N33/66

CPC分类号： G01N33/66 , G01N2400/00 , G01N2800/285 , G01N2800/52

摘要： The invention provides the art with a powerful diagnostic method of distinguishing relapse-remitting MS subjects from progressive MS subjects, based on the measurement of serum concentrations of N-acetylglucosamine (GlcNAc,), for the first time enabling rapid diagnosis of the progressive form of MS. GlcNAc serum concentration can also be used to assess neurodegenerative status and MS progression in subjects suffering from MS or other neurological conditions. The methods of the invention also allow for the identification of new therapeutics for MS and other neurological conditions and also enables the personalized efficacy assessment of a potential therapy for an MS subject.