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Patent Agency Ranking
1.发明公开公开(公告)号：US20230233517A1
公开(公告)日：2023-07-27
申请号：US17852475
申请日：2022-06-29
Inventor： Ding Xue , Yu Peng , Man Zhang , Lingjun Zheng , Qian Liang , Hanzeng Li , Jau-Song Yu , Jeng-Ting Chen
IPC: A61K31/353 , A61K31/336 , A61K31/4025 , A61K31/7048
CPC classification number: A61K31/353 , A61K31/336 , A61K31/4025 , A61K31/7048
Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
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公开(公告)号：US09518090B2
公开(公告)日：2016-12-13
申请号：US14431622
申请日：2013-09-26
IPC: C07K7/08 , C07K7/06 , G01N33/50 , C12N15/113 , A61K38/00
CPC classification number: A61K38/04 , A61K38/00 , C07K7/06 , C07K7/08 , C12N15/1131 , C12N15/1135 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2330/50 , G01N33/5008 , G01N33/5085 , G01N2333/02 , G01N2500/02 , G01N2500/10
Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.
Abstract translation: 本发明提供用于治疗乙型肝炎病毒（HBV）感染的组合物和方法以及鉴定适合于治疗HBV感染的化合物或组合物的方法。 此外，本发明提供了可用于筛选可抑制哺乳动物HBV复制或治疗HBV感染的化合物或组合物的合适的非哺乳动物动物模型。 特别地，本发明提供通过抑制HBV x蛋白与Bcl-2家族蛋白之间的相互作用或通过降低Bcl-2家族蛋白的表达水平来治疗乙型肝炎感染的组合物和方法。
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公开(公告)号：US10155020B2
公开(公告)日：2018-12-18
申请号：US15343473
申请日：2016-11-04
Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.
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公开(公告)号：US20170042960A1
公开(公告)日：2017-02-16
申请号：US15343473
申请日：2016-11-04
IPC: A61K38/04 , G01N33/50 , C12N15/113
CPC classification number: C07K7/08 , A61K38/00 , A61K38/04 , C07K7/06 , C12N15/1131 , C12N15/1135 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2330/50 , G01N33/5008 , G01N33/5085 , G01N2333/02 , G01N2500/02 , G01N2500/10
Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.
Abstract translation: 本发明提供用于治疗乙型肝炎病毒（HBV）感染的组合物和方法以及鉴定适合于治疗HBV感染的化合物或组合物的方法。 此外，本发明提供了可用于筛选可抑制哺乳动物HBV复制或治疗HBV感染的化合物或组合物的合适的非哺乳动物动物模型。 特别地，本发明提供通过抑制HBV x蛋白与Bcl-2家族蛋白之间的相互作用或通过降低Bcl-2家族蛋白的表达水平来治疗乙型肝炎感染的组合物和方法。
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公开(公告)号：US20150232513A1
公开(公告)日：2015-08-20
申请号：US14431622
申请日：2013-09-26
IPC: C07K7/08 , C07K7/06 , G01N33/50 , C12N15/113
CPC classification number: A61K38/04 , A61K38/00 , C07K7/06 , C07K7/08 , C12N15/1131 , C12N15/1135 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2330/50 , G01N33/5008 , G01N33/5085 , G01N2333/02 , G01N2500/02 , G01N2500/10
Abstract: The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein.
Abstract translation: 本发明提供用于治疗乙型肝炎病毒（HBV）感染的组合物和方法以及鉴定适合于治疗HBV感染的化合物或组合物的方法。 此外，本发明提供了可用于筛选可抑制哺乳动物HBV复制或治疗HBV感染的化合物或组合物的合适的非哺乳动物动物模型。 特别地，本发明提供通过抑制HBV x蛋白与Bcl-2家族蛋白之间的相互作用或通过降低Bcl-2家族蛋白的表达水平来治疗乙型肝炎感染的组合物和方法。
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