公开(公告)号：US20220265835A1

公开(公告)日：2022-08-25

申请号：US17622112

申请日：2020-06-26

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Erez Bublil ,  Frank Glavin ,  Marcia Sellos-Moura ,  Jan P. Kraus ,  Tomas Majtan ,  Randy Wanner ,  Orhan Causevic

IPC: A61K47/60 ,  A61K47/26 ,  A61K47/02 ,  A61K9/19 ,  A61P43/00

Abstract: The present disclosure provides formulations for a drug product comprising a PEGylated CBS protein having the amino acid sequence of SEQ ID NO: 1. Dosages and dosing regimens are provided for treatment of homocystinuria in a subject in need thereof. Additionally, the dosages and dosing regimens are also provided to reduce the level of homocysteine (Hcy) or increase the levels of cysteine (Cys) and/or cystathionine (Cth) in a subject in need thereof.